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FLASH GENE
Symbol BLID contributors: mct/npt - updated : 19-12-2009
HGNC name BH3-like motif containing, cell death inducer
HGNC id 33495
Location 11q24.1      Physical location : 121.986.062 - 121.986.923
Synonym name
  • BRCC2 protein
  • BH3-like domain containing protein 2
  • breast cancer cell 2
    • Synonym symbol(s) MGC163233, MGC163235, BRCC2
    DNA
    TYPE functioning gene
    STRUCTURE 0.86 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 862 12 108 - Nakanishi (2009)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Visualeyeretina   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    text ectopic expression also found in both the cytosol and mitochondria
    basic FUNCTION
  • functioning as a proapoptotic molecule
  • may be inducing a caspase-dependent mitochondrial pathway of cell death
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to high myopia
    Variant & Polymorphism SNP SNP, rs577948, at chromosome 11q24.1, associated with high myopia (Nakanishi 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS