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FLASH GENE
Symbol BLCAP contributors: mct/npt - updated : 05-05-2010
HGNC name bladder cancer associated protein
HGNC id 1055
Location 20q11.23      Physical location : 36.145.819 - 36.156.333
Synonym name bladder cancer related protein (10kD)
Synonym symbol(s) BC10
DNA
TYPE functioning gene
STRUCTURE 10.48 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text all variants encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2087 - 87 - Yao (2007)
- - 2119
- - 2052 - 87 - -
- - 2046 - 87 - -
- - 2216 - 87 - -
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
digestivemouthgingiva   
Endocrinethyroid   highly
Nervousbrain   highly
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Bc10
Homologene
FAMILY
  • BLCAP family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • may play a role not only in regulating cell proliferation but also in coordinating apoptosis and cell cycle via a novel way independent of TP53 and NFkappaB
  • potential tumor suppressor gene in cervical carcinoma
  • tumour suppressor that limits cell proliferation and stimulates apoptosis (Schultz 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in bladder cancer in progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS