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FLASH GENE
Symbol BIRC8 contributors: mct/npt - updated : 30/09/2008
HGNC name baculoviral IAP repeat-containing 8
HGNC id 14878
Location 19q13.3-q13.4      Physical location : 53.792.855 - 53.794.875
Synonym name
  • (IAP)-like protein 2
  • inhibitor of apoptosis-like protein 2
  • testis-specific inhibitor of apoptosis
  • Synonym symbol(s) ILP2, ILP-2
    DNA
    TYPE functioning gene
    STRUCTURE 2.02 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure intronless, two BIR-like domains in the 5'utr
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2047 27 236 - Shin (2005)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   moderately
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one BIR domain
  • a C terminal Ring zinc finger motif
  • HOMOLOGY
    intraspecies homolog to to the C terminal of BIRC4
    Homologene
    FAMILY
  • baculovirus IAP-related family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • putatively antiapoptotic in the spermatocytes and spermatids, showing strong protection against BAX-mediated apoptosis
  • requires assistance from unidentified cellular factors to be an effective inhibitor of apoptosis
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BAX
  • caspase 9
  • cell & other
    REGULATION
    inhibited by weakly by SMAC
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS