Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BIN2 contributors: mct - updated : 17-03-2008
HGNC name bridging integrator 2
HGNC id 1053
Location 12q13      Physical location : 51.674.822 - 51.717.938
Genatlas name BAR adaptor gene 2
Synonym name breast cancer associated protein
Synonym symbol(s) BRAP1
DNA
TYPE like-sequence
STRUCTURE 43.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2228 - 565 - Scherer (2006)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Lymphoid/Immunespleen   highly
 thymus   highly
cell lineage hematopoietic cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal BAR (Bin1, Amphiphysin, Rv167) domain
  • a long C terminal segment lacking the Myc interaction
  • a SH3 domain
  • HOMOLOGY
    Homologene
    FAMILY BAR proteins family
    CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION encoding a nonredundant function in the BAR adaptor gene family
    CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text differentiation of granulocytic cells
    PATHWAY
    metabolism
    signaling
    a component complexing with BIN1 but not AMPH, in a BAR domain-dependent manner
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other upregulated during monocyte differentiation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS