Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BIN2 contributors: mct - updated : 17-03-2008
HGNC name bridging integrator 2
HGNC id 1053
Location 12q13      Physical location : 51.674.822 - 51.717.938
Genatlas name BAR adaptor gene 2
Synonym name breast cancer associated protein
Synonym symbol(s) BRAP1
DNA
TYPE like-sequence
STRUCTURE 43.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC113251 12q13.12 c-Mpl binding protein FLJ34278 12q13.12-q13.13 hypothetical protein FLJ34278 ATF1 12q13.1-q13.2 activating transcription factor 1 MGC57341 12q13.13 hypothetical protein MGC57341 DKFZP586A0522 12q13.13 DKFZP586A0522 protein SLC11A2 12q13.1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 HCCR1 12q13.13 cervical cancer 1 protooncogene C12orf22 12q13.11-q13.12 chromosome 12 open reading frame 22 TFCP2 12q13.1 transcription factor CP2 POU6F1 12q13.1 POU domain, class 6, transcription factor 1 DAZAP2 2q33-q34 DAZ associated protein 2 LOC57228 12q13.13 hypothetical protein from clone 643 BIN2 4q22.1 bridging integrator 2 ELA1 12q13 elastase 1, pancreatic GALNT6 12q13 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) LOC387857 12 LOC387857 SLC4A8 12q13 solute carrier family 4, sodium bicarbonate cotransporter, member 8 SCN8A 12q13 sodium channel, voltage gated, type VIII, alpha FLJ33996 12q13.13 hypothetical protein FLJ33996 DKFZp686O1689 12q13.13 hypothetical protein DKFZp686O1689 ACVRL1 12q13 activin A receptor type II-like 1 ACVR1B 12q13 activin A receptor, type IB GRASP 12q13.13 GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein NR4A1 12q13 nuclear receptor subfamily 4, group A, member 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2228 - 565 - Scherer (2006)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Lymphoid/Immunespleen   highly
 thymus   highly
cell lineage hematopoietic cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal BAR (Bin1, Amphiphysin, Rv167) domain
  • a long C terminal segment lacking the Myc interaction
  • a SH3 domain
  • HOMOLOGY
    Homologene
    FAMILY BAR proteins family
    CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION encoding a nonredundant function in the BAR adaptor gene family
    CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text differentiation of granulocytic cells
    PATHWAY
    metabolism
    signaling
    a component complexing with BIN1 but not AMPH, in a BAR domain-dependent manner
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other upregulated during monocyte differentiation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS