Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BIK contributors: mct/pgu - updated : 23-05-2012
HGNC name BCL2-interacting killer (apoptosis-inducing)
HGNC id 1051
Location 22q13.2      Physical location : 43.506.756 - 43.525.717
Synonym name apoptosis inducer NBK
Synonym symbol(s) NBK, BP4, BBC1, BIP1
DNA
TYPE functioning gene
STRUCTURE 18.96 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D22S283 - ADSL - BIK - D22S272 - qter
Authors Gene Map (98)
Physical map
CYP2D8P2 22q11.22-q11.23 cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2 CYP2D8P1 22q13.2-q13.31 cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 1 TCF20 22q13.3 transcription factor 20 (AR1) LOC388906 22 hypothetical gene supported by BC039496 LOC150371 22q13.31 hypothetical LOC150371 NFAM1 22q13.31 NFAT activation molecule 1 SERHL 22q13.2-q13.31 serine hydrolase-like CGI-96 22q13.2-q13.31 CGI-96 protein dJ222E13.1 22q13 kraken-like dJ222E13.2 22q13.31 similar to CGI-96 PDIP46 RNU12P 22 RNA, U12 small nuclear pseudogene DIA1 22q13.2 diaphorase (NADH) (cytochrome b-5 reductase) A4GALT 22q13.2 alpha 1,4-galactosyltransferase LOC388907 22 similar to ribosomal protein L5; 60S ribosomal protein L5 LOC391337 22 similar to hypothetical protein ARFGAP3 22q13.2-q13.3 ADP-ribosylation factor GTPase activating protein 3 PACSIN2 22q13.31 protein kinase C and casein kinase substrate in neurons 2 TTLL1 22q13.1 tubulin tyrosine ligase-like 1 BIK 22q13.31 BCL2-interacting killer (apoptosis-inducing) MT 22q13.31 malonyl-CoA:acyl carrier protein transacylase (malonyltransferase) BZRP 22q13.31 benzodiazapine receptor (peripheral) KIAA0153 22q13.31 benzodiazapine receptor (peripheral) SCUBE1 22q13.2-q13.3 signal peptide, CUB domain, EGF-like 1 DKFZp547I094 22q13.31 hypothetical protein DKFZp547I094 LOC388908 22 similar to chromosome 22 open reading frame 1; adult brain protein 239 FLJ23588 22q13.1-q13.33 CAP-binding protein complex interacting protein 1 YWHAQP2 22q12-qter YWHAQ pseudogene 2 HMG17L1 22q13.31 high-mobility group (nonhistone chromosomal) protein 17-like 1 SULT4A1 22q13.2-q13.31 sulfotransferase family 4A, member 1 LOC150379 22q13.31 GS2 like C22orf20 22q13.31 chromosome 22 open reading frame 20 CGI-51 22q13.31 CGI-51 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 963 - 160 - 2006 17047080
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon lowly
 stomach   lowly
Lymphoid/Immunelymph node   moderately
 tonsils   highly
Reproductivemale systemprostate  lowly
Urinarykidney   lowly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymhoid/Immunelymphocyte
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • BH3 containing protein, as BAX and BAK1
  • HOMOLOGY
    Homologene
    FAMILY
  • BCL2 family
  • CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope
    text
  • colocalizing with cytoplasmic and nuclear membranes
  • intracytoplasmic membrane
  • single-pass membrane protein
  • predominantly localized to the endoplasmic reticulum (predominantly to the outer membrane of the endoplasmic reticulum) where it regulates BAX/BAK-dependent release of Ca2+ from the endoplasmic reticulum stores and cooperates with other BH3-only proteins such as PMAIP1 to cause rapid release of cytochrome c from mitochondria and activate apoptosis
  • basic FUNCTION
  • acting as a likely target for antiapoptotic proteins
  • inducing apoptosis through the mitochondrial pathway by mobilizing calcium from the ER to the mitochondria and remodeling the mitochondrial cristae
  • also inducing non-apoptotic cell death
  • involved in the selection of mature B cells
  • critical effector in apoptosis induced by toxins, cytokines virus infections
  • proapoptotic tumor suppressor
  • plays a critical role in promotion of anti-estrogen-induced cell death in breast cancer cells
  • has a role in both, apoptosis induction and sensitivity to oxidative stress in myeloma cells
  • inactivate BCL2 through complex formation
  • key mediator of estrogen-starvation and anti-estrogen induced apoptosis
  • stronger inducer of apoptosis than PMAIP1, and when expressed simultaneously, a combinative effect was observed
  • initiator of mitochondrial apoptosis, and its expression is induced by proapoptotic signals, including DNA damage
  • TUT1-control of BIK expression and apoptosis is regulated by nuclear PIP5K1A and PRKCD signaling
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • BIK not only forms complex with BCL2, but it also forms complex with HSPA5
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • the cellular survival-promoting proteins BCL2 as well as with adenovirus E1b-19kDa protein
  • participating in the cleavage of BIK, a proapoptotic member of the BCL2 family
  • interaction of HSPA5 with BIK does not require its BH3 domain, which has been implicated in all previous BIK protein interactions
  • interacting with HSPA5 (HSPA5 confers resistance to apoptosis induced by BIK and PMAIP)
  • cell & other
    REGULATION
    activated by
  • TP53
  • several anti-cancer drugs
    induced by
  • strongly induced in cancer cells treated with chemotherapeutic agents
  • E2F in cancer cells
  • ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    mutated in B-cell lymphomas
    tumoral   deletion    
    chromosomal deletions encompassing BIK locus or epigenetic silencing in cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    prominent target for anti-cancers drugs that inhibit proteasomal functions
    cancer  
    therapeutic molecule in gene therapy-based approaches to treat difficult cancers
    ANIMAL & CELL MODELS