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FLASH GENE
Symbol BID contributors: mct/pgu - updated : 18-09-2015
HGNC name BH3 interacting domain death agonist
HGNC id 1050
Location 22q11.21      Physical location : 18.216.905 - 18.257.258
Synonym name
  • apoptic death agonist
  • desmocollin type 4
  • p22 BID
  • human BID coding sequence
  • BID isoform Si6
  • BID isoform L(2)
  • Synonym symbol(s) FP497, MGC15319, MGC42355
    DNA
    TYPE functioning gene
    STRUCTURE 40.35 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see ATP6V1E
    Physical map
    ADPRTL4 22q11.1 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 4 VWFP 22q11.22-q11.23 von Willebrand factor pseudogene MGC57211 22q11.21 hypothetical protein MGC57211 LOC391288 22 similar to zinc finger protein LOC391289 22 similar to GRB2-associated binding protein 2 isoform a; Grb2-associated binder 2 VN1R9P 22 vomeronasal 1 receptor 9 pseudogene LOC391290 22 similar to acetyl-Coenzyme A synthetase 3; medium-chain acyl-CoA synthetase; Butyrate CoA ligase IL17R 22q11.1 interleukin 17 receptor CECR6 22q11.2 cat eye syndrome chromosome region, candidate 6 CECR5 22q11.2 cat eye syndrome chromosome region, candidate 5 CECR1 22q11.2 cat eye syndrome chromosome region, candidate 1 RPL32L2 22q11.1 ribosomal protein L32-like 2 CLCP1 22q11.2 Charot-Leyden crystal protein pseudogene 1 CECR2 22q11.2 cat eye syndrome chromosome region, candidate 2 SLC25A18 22q11.2 solute carrier family 25, (mitochondrial carrier), member 18 ATP6V1E1 22q11.21 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1 BCL2L13 22q11.2 BCL2-like 13 (apoptosis facilitator) BID 22q11.21 BH3 interacting domain death agonist FLJ40542 22q11.21 hypothetical protein FLJ40542 LOC388843 22 LOC388843 KIAA0819 22q11.21 KIAA0819 protein MICAL3 22q11.21 flavoprotein oxidoreductase MICAL3 PEX26 22q11.21 peroxisome biogenesis factor 26 TUBA8 22q11 tubulin, alpha 8 USP18 22q11.21 ubiquitin specific protease 18 LOC391291 22 LOC391291 LOC388844 22 hypothetical gene supported by AK097777; AK128837; AK129567; BC040613 LOC220522 22q11.21 similar to Gamma-glutamyltranspeptidase 1 precursor (Gamma-glutamyltransferase 1) (CD224 antigen) LOC391292 22 similar to immunoglobulin superfamily, member 3; immunoglobin superfamily, member 3 LOC386610 22q11.21 E2F transcription factor 6 pseudogene LOC388845 22 LOC388845 LOC388846 22 similar to hypothetical protein DKFZp434P211.1 - human (fragments) LOC388847 22 similar to breakpoint cluster region isoform 1 LOC391293 22 LOC391293 LOC388848 22 LOC388848 DGCR6 22q11.21 DiGeorge syndrome critical region gene 6 PRODH 22q11.21 proline dehydrogenase (oxidase) 1 DGCR5 22q11 DiGeorge syndrome critical region gene 5 (non-coding) LOC391294 22 similar to POM121 membrane glycoprotein-like 1 LOC343830 22q11.21 similar to carbonic anhydrase XV DGCR2 22q11.21 DiGeorge syndrome critical region gene 2 LOC391295 22 similar to serine/threonine kinase FKSG81; spermiogenesis associated 4 STK22B 22q11.2 serine/threonine kinase 22B (spermiogenesis associated) DGCR14 22q11.21 DiGeorge syndrome critical region gene 14
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2214 - 195 - 2005 15899861
    6 - 1101 26.6 241 predominantly in tissues hemopoietic, spleen and bone marrow, also expressed at high levels in cerebral and cerebellar cortex, as might be expected given the importance of BID in regulating neuronal cell death 2005 15899861
  • also called BID(EL)
  • an additional 45 amino acids at the N terminus that do not contain any recognized conserved domains
  • 5 splicing 2144 11.3 99 lung, pancreas 2005 15899861
  • also called BID(ES)
  • only the BID sequence downstream of the BH3 domain
  • induces apoptosis but is also able to partially inhibit the pro-apoptotic effects of truncated BID
  • 5 - 2006 15 99 - 2013 23744079
  • also called BIDT
  • truncated form
  • formed upon cleavage of BID by protease caspase-8, and can promote the oligomerization/insertion of BAX into the outer mitochondrial membrane
  • can induce apoptosis by promoting BAX activation
  • interaction of MTCH2 and tBID is a potential target for therapeutic control of BID initiated cell death
  • contains the BH3 domain and serves as the active form of BID: it translocates to the mitochondria and activates BAX/BAK1 homo-oligomerization in the outer mitochondrial membrane
  • MTCH2 recruits tBID to the mitochondria, and consequently tBID activates the BAX protein to initiate apoptosis
  • 6 - 2128 - 195 - 2005 15899861
    6 - 1935 - 99 - 2005 15899861
    4 - 2272 - 99 - 2005 15899861
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon   Homo sapiens
     liver    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight alpha helices, containing from the N terminal
  • three BCL2 homology domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Bid
    Homologene
    FAMILY
  • BCL-2 family of cell death regulators
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    text
  • expressed in cytosol and translocated to mitochondria after proteolytic activation by CASP8
  • truncated BID (tBID) translocates to the mitochondria, facilitates the release of cytochrome c, and activates the intrinsic pathways
  • binds to the membrane, and undergoes slow structural rearrangements that result in an equilibrium between two major tBID conformations on the membrane
  • basic FUNCTION
  • death agonist (inducing apoptosis), inducing mitochondrial damage by caspase-8 cleavage
  • acting downstream of MAPK8 in TNF signaling to mitochondria
  • important role in activating the mitochondrial apoptosis pathway after death receptor engagement, particularly in hepatocytes
  • regulates hepatocyte proliferation by positively affecting [Ca(2+)](ER) homeostasis, which could be important for liver regeneration and carcinogenesis
  • having a unique role in signaling of apoptosis, because it links the death receptor signaling pathway to the mitochondrial signaling pathway mediated by BCL2 proteins
  • mediator of mitochondrial damage induced by caspase-8 (CASP8)
  • a pro-apoptotic BCL-2 family member playing an essential role in initiating this program
  • involved in the Bak/Bax-dependent mitochondrial cell death pathway
  • putative cathepsin B target in SPARC-induced apoptosis
  • novel role of BID in inflammation and immunity independent of its apoptotic function
  • potential proximal regulator of the NOD1 signalling complex
  • involved in tumor necrosis factor death receptor I (TNFRI)-mediated destructive signal transduction pathways such as cell dysfunction or neurodegeneration in the temporal cortex of patients with Parkinson disease
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with either agonists (BAX) or antagonists (BCL2) of apoptosis
  • cleaved in response to apoptotic stimuli into two fragments, p7 and tBid (p15), that are held together by strong hydrophobic interactions until the complex binds to membranes (9)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAPK8, DIABLO for TNF-mediated CASP8 cleavage and apoptosis
  • GZMK directly processes BID to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death
  • preferentially associated with the CK2alpha (CSNK2A1) subunit
  • BID, BCL2L11, and BBC3 are required to activate BAX- and BAK1-dependent mitochondrial apoptosis
  • CAV1 regulates hyperoxia/ROS-induced apoptosis through interactions with FAS and BID, probably via FAS palmitoylation and CAV1 Y14 phosphorylation, respectively
  • interacts with NOD1, NOD2 and the IKB kinase (IKK) complex, impacting NFKB and extracellular signal-regulated kinase (ERK) signalling
  • BID associates with RPA1 and stimulates the recruitment and/or stabilization of ATR-ATRIP to the DNA damage sensor complex
  • activates BAK1 to mitochondrial outer-membrane permeabilization (MOMP), which leads to apoptosis
  • KAT2B and TADA3 regulate BID processing via PACS2, to modulate the mitochondrial cell death pathway in response to GZMB
  • role for MOAP1 in FAS signaling in the liver by promoting MTCH2-mediated BID recruitment to mitochondria
  • ANXA1 interacted with the BID (BH3-interacting-domain death agonist) promoter directly
  • cell & other
    REGULATION
    activated by CASP8
    Other regulated in part by alternative splicing
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    loss of BID function impaired the ability of NOD2 but not TLR3 to trigger tissue repair responses upon injury
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    with its substrate CTSB were shown to be molecular links between apoptosis and autophagy in breast cancer MCF-7 cells exposed to the cytostatic drug, camptothecin
    ANIMAL & CELL MODELS
  • Bid-/- mice are unresponsive to local or systemic exposure to NOD agonists or their protective effect in experimental colitis