Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BGLAP contributors: - updated : 20-06-2007
HGNC name bone gamma-carboxyglutamate (gla) protein (osteocalcin)
HGNC id 1043
Location 1q25-q31      Physical location : 156.211.950 - 156.213.112
Synonym name
  • gamma-carboxyglutamic acid-containing protein
  • osteocalcin
  • bone Gla protein
    • Synonym symbol(s) BGLA, BGP, PMF1
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     4 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D1S189 - D1S252 - D1S305 - D1S303 - BGLAP /D1S3737 - D1S2721 - D1S2624 - CRP - SPTA1 - APOA2 APOA2 - D1S194 qter
    Authors Raymond (99)
    Physical map
    YAP 1q21.3 hepatoma-derived growth factor (high-mobility group protein 1-like) DAP3 1q21 death associated protein 3 LOC388705 1 similar to misato FLJ20203 1q22 hypothetical protein FLJ20203 SYT11 1q21.2 synaptotagmin XI RIT1 1q21.2 Ras-like without CAAX 1 KIAA0907 1q21 Ras-like without CAAX 1 GPR100 1q22 G protein-coupled receptor 100 ARHGEF2 1q11-q21 rho/rac guanine nucleotide exchange factor (GEF) 2 SSR2 1q21-q23 signal sequence receptor, beta (translocon-associated protein beta) C1orf6 1q21 chromosome 1 open reading Frame 6 MAPBPIP 1q22 mitogen-activated protein-binding protein-interacting protein RAB25 1q21.2 RAB25, member RAS oncogene family LOC92312 1q22-q23.1 hypothetical protein LOC92312 LMNA 1q21.2-q21.3 lamin A/C FLJ12287 1q22 hypothetical protein FLJ12287 similar to semaphorins LOC388706 1 LOC388706 KIAA0446 1q23.1 KIAA0446 gene product PMF1 1q12-q21.1 polyamine-modulated factor 1 BGLAP 1q25-q31 bone gamma-carboxyglutamate (gla) protein (osteocalcin) PAQR6 1q23.1 progestin and adipoQ receptor family member VI EST1B 1q21.2 Est1p-like protein B MGC13102 1q23.1 hypothetical protein MGC13102 MGC31963 1q23.1 kidney predominant protein NCU-G1 LOC391104 1 similar to Von Hippel-Lindau disease tumor suppressor (pVHL) (G7 protein) CCT3 1q23 chaperonin containing TCP1, subunit 3 (gamma) SSTK-IP 1q23.1 SSTK-interacting protein RHBG 1q21.3 Rhesus blood group, B glycoprotein CROC4 1q12-q25 Rhesus blood group, B glycoprotein MEF2D 1q12-q23 MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) IQGAP3 1q21.3 IQ motif containing GTPase activating protein 3 LOC164118 1q23.1 similar to RIKEN cDNA A430025D11 APOA1BP 1q21.2 apolipoprotein A-I binding protein FLJ20249 1q22 hypothetical protein FLJ20249 BRAL1 1q22 hypothetical protein FLJ20249 BCAN 1q23-q31 hypothetical protein FLJ20249 NES 1q23.1 nestin CRABP2 1q21.3 cellular retinoic acid binding protein 2 FLJ12671 1q23.1 hypothetical protein FLJ12671 CGI-41 1q23.1 CGI-41 protein MRPL24 1q21-q22 mitochondrial ribosomal protein L24 HDGF Xq25 hepatoma-derived growth factor (high-mobility group protein 1-like) PRCC 1q21.2 papillary renal cell carcinoma (translocation-associated) SH2D2A 1q21 SH2 domain protein 2A
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
    Endocrineparathyroid    
    Skeletonappendicularpectoral girdleclavicle  
     axialskull   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		three GLA residues
    HOMOLOGY
    Homologene
    FAMILY osteocalcin/matrix gla-protein family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • constituant of the total bone protein
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text cellular growth and mineralization
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • it binds strongly to apatite and calcium
    • protein
    cell & other
    REGULATION
    Other regulated by AP1 related protein and CBFA1 transcription factor
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism other Hind III polymorphism putatively influencing bone density and osteoblast growth
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS