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FLASH GENE
Symbol BGLAP contributors: mct - updated : 19-10-2013
HGNC name bone gamma-carboxyglutamate (gla) protein (osteocalcin)
HGNC id 1043
Location 1q22      Physical location : 156.211.950 - 156.213.112
Synonym name
  • gamma-carboxyglutamic acid-containing protein
  • osteocalcin
  • bone Gla protein
  • Synonym symbol(s) BGLA, BGP, PMF1, OCN, OC
    DNA
    TYPE functioning gene
    STRUCTURE 1.17 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • in the proximal promoter a minimal C/T-rich motif, termed BGLAP-CxRE (connexin-response element) that binds Sp1 and Sp3 in a gap junction-dependent manner
  • . ATF6 increases BGLAP transcription via directly binding to BGLAP promoter
  • MAPPING cloned Y linked N status confirmed
    Map cen - D1S189 - D1S252 - D1S305 - D1S303 - BGLAP /D1S3737 - D1S2721 - D1S2624 - CRP - SPTA1 - APOA2 APOA2 - D1S194 qter
    Authors Raymond (99)
    Physical map
    YAP 1q21.3 hepatoma-derived growth factor (high-mobility group protein 1-like) DAP3 1q21 death associated protein 3 LOC388705 1 similar to misato FLJ20203 1q22 hypothetical protein FLJ20203 SYT11 1q21.2 synaptotagmin XI RIT1 1q21.2 Ras-like without CAAX 1 KIAA0907 1q21 Ras-like without CAAX 1 GPR100 1q22 G protein-coupled receptor 100 ARHGEF2 1q11-q21 rho/rac guanine nucleotide exchange factor (GEF) 2 SSR2 1q21-q23 signal sequence receptor, beta (translocon-associated protein beta) C1orf6 1q21 chromosome 1 open reading Frame 6 MAPBPIP 1q22 mitogen-activated protein-binding protein-interacting protein RAB25 1q21.2 RAB25, member RAS oncogene family LOC92312 1q22-q23.1 hypothetical protein LOC92312 LMNA 1q21.2-q21.3 lamin A/C FLJ12287 1q22 hypothetical protein FLJ12287 similar to semaphorins LOC388706 1 LOC388706 KIAA0446 1q23.1 KIAA0446 gene product PMF1 1q12-q21.1 polyamine-modulated factor 1 BGLAP 1q25-q31 bone gamma-carboxyglutamate (gla) protein (osteocalcin) PAQR6 1q23.1 progestin and adipoQ receptor family member VI EST1B 1q21.2 Est1p-like protein B MGC13102 1q23.1 hypothetical protein MGC13102 MGC31963 1q23.1 kidney predominant protein NCU-G1 LOC391104 1 similar to Von Hippel-Lindau disease tumor suppressor (pVHL) (G7 protein) CCT3 1q23 chaperonin containing TCP1, subunit 3 (gamma) SSTK-IP 1q23.1 SSTK-interacting protein RHBG 1q21.3 Rhesus blood group, B glycoprotein CROC4 1q12-q25 Rhesus blood group, B glycoprotein MEF2D 1q12-q23 MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) IQGAP3 1q21.3 IQ motif containing GTPase activating protein 3 LOC164118 1q23.1 similar to RIKEN cDNA A430025D11 APOA1BP 1q21.2 apolipoprotein A-I binding protein FLJ20249 1q22 hypothetical protein FLJ20249 BRAL1 1q22 hypothetical protein FLJ20249 BCAN 1q23-q31 hypothetical protein FLJ20249 NES 1q23.1 nestin CRABP2 1q21.3 cellular retinoic acid binding protein 2 FLJ12671 1q23.1 hypothetical protein FLJ12671 CGI-41 1q23.1 CGI-41 protein MRPL24 1q21-q22 mitochondrial ribosomal protein L24 HDGF Xq25 hepatoma-derived growth factor (high-mobility group protein 1-like) PRCC 1q21.2 papillary renal cell carcinoma (translocation-associated) SH2D2A 1q21 SH2 domain protein 2A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1001 - 211 - 2000 10486212
    3 - 940 - 220 - 2000 10486212
    3 - 805 - 175 - 2000 10486212
    3 - 794 - 142 - 2000 10486212
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
    Endocrineparathyroid    
    Skeletonappendicularpectoral girdleclavicle  
     axialskull   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    three GLA residues
    HOMOLOGY
    Homologene
    FAMILY osteocalcin/matrix gla-protein family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • constituant of the total bone protein
  • possible link between adipose tissue and BGLAP in the regulation of metabolism
  • plays important roles in mineralization and calcium ion homeostasis
  • non-collagenous, vitamin K-dependent protein secreted in the late stage of osteoblasts differentiation
  • acts as a regulator of bone mineralization, and regulates osteoblast and osteoclast activity
  • it is presumable that BGLAP also acts on blood vessels by inducing angiogenesis and pathological mineralization
  • bone matrix protein that regulates hydroxyapatite size and shape through its vitamin-K-dependent, gamma-carboxylated form
  • important regulator of energy metabolism
  • attenuatespotentially ER stress and rescues impaired insulin sensitivity in insulin resistance via the NFKB signaling pathway
  • noncollagenous protein found in bone matrix and involved in mineralization and calcium ion homeostasis, that is one of the major bone morphogenetic markers
  • modulates reproductive function in humans
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text cellular growth and mineralization
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • it binds strongly to apatite and calcium
  • protein
  • GPRC6A is a candidate for mediating the response to BGLAP in the bone-pancreas endocrine loop regulating insulin signaling
  • unphosphorylated HSPB1 has an inhibitory effect on BGLAP synthesis, but has a stimulatory effect on mineralization, in osteoblasts
  • SP7 could act via the non-canonical Sp1/Sp3-binding element to regulate BGLAP transcription
  • ATF4 activates BGLAP in osteoblasts and indian hedgehog (IHH) in chondrocytes
  • TP53 can bind to the human osteocalcin promoter (may directly target the BGLAP and positively affect its gene expression)
  • BMP2 induces osteoblast differentiation through RUNX2-dependent ATF6 expression, which directly regulates BGLAP transcription
  • NACA acts as a transcriptional coactivator of the Osteocalcin gene
  • KDM6B plays important roles in osteoblast differentiation and regulates the expressions of IBSP and BGLAP via transcription factors RUNX2 and SP7
  • cell & other
    REGULATION
    Other regulated by AP1 related protein and CBFA1 transcription factor
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism other Hind III polymorphism putatively influencing bone density and osteoblast growth
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    may offer novel opportunities for treatment of obesity and diabetes
    obesity  
    may offer novel opportunities for treatment of obesity and diabetes
    ANIMAL & CELL MODELS
  • Osteocalcin-deficient mice exhibit increased levels of luteinizing hormone (LH), a pituitary hormone that regulates sex steroid synthesis in the testes