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FLASH GENE
Symbol BEX1 contributors: mct/npt - updated : 20-03-2018
HGNC name brain expressed, X-linked 1
HGNC id 1036
Location Xq22.1      Physical location : 102.317.580 - 102.319.168
Synonym name
  • uncharacterized hypothalamus protein HBEX2
  • ovarian granulosa cell 13.0 kDa protein hGR74
  • Synonym symbol(s) BEX2, HBEX2, HGR74-h
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text BEX1 and its homologue BEX2 have highly correlated expression and are part of a cluster enriched for ER response and apoptosis genes
    STRUCTURE 1.59 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 862 - 125 - Alvarez (2005)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas   highly
    Nervousbrainhindbraincerebellum  
     brainforebraincerebral lobetemporal lobe 
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Rex3
    intraspecies paralog to BEX2
    Homologene
    FAMILY
  • BEX family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • with NGFRAP1 interact with NGFR and modulate nerve growth factor (NGF) signaling through nuclear factor-kappaB (NF-kappaB) to regulate cell cycle, apoptosis, and differentiation in neural tissues (Naderi 2007)
  • epigenetic inactivation of BEX1 supports its role as a candidate tumour suppressor gene in intracranial ependymoma
  • while BEX1 and NGFRAP1 act as tumor suppressors, BEX2 seems to act as an oncogene
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind to NGFR intracellular domain and acts as a link between neurotrophin signaling, the cell cycle, and neuronal differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    is lost in a subgroup of patients with acute myeloid leukemia (AML) and chronic myeloid leukemia (CML)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS