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FLASH GENE
Symbol BEX1 contributors: mct/npt - updated : 20-03-2018
HGNC name brain expressed, X-linked 1
HGNC id 1036
Location Xq22.1      Physical location : 102.317.580 - 102.319.168
Synonym name
  • uncharacterized hypothalamus protein HBEX2
  • ovarian granulosa cell 13.0 kDa protein hGR74
  • Synonym symbol(s) BEX2, HBEX2, HGR74-h
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text BEX1 and its homologue BEX2 have highly correlated expression and are part of a cluster enriched for ER response and apoptosis genes
    STRUCTURE 1.59 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ALEX2 Xq21.33-q22.2 ALEX2 protein GKP6 Xq22-q23 glycerol kinase pseudogene 6 NXF5 Xq22 nuclear RNA export factor 5 KIAA1789 Xq21 KIAA1789 protein my048 Xq22.1-q22.3 my048 protein LOC158931 Xq22.1 similar to hypothetical protein MGC15737 LOC340542 Xq22.1 hypothetical protein LOC340542 NXF2 Xq22-q23 nuclear RNA export factor 2 TMSNB Xq21.33-q22.3 thymosin, beta, identified in neuroblastoma cells LOC139707 Xq22.1 similar to checkpoint suppressor 1 NXF4 Xq22 nuclear RNA export factor 4 FLJ12969 Xq22.1-q22.3 hypothetical protein FLJ12969 GASP Xq22.1 G protein-coupled receptor-associated sorting protein LOC114928 Xq22.1 hypothetical protein BC013576 KIAA1701 Xq23 KIAA1701 protein MTND2P2 Xq22.2 NADH dehydrogenase 2 pseudogene 2 LOC286526 Xq22.2 Ras-like GTPase-like BEX1 Xq21-q23 brain expressed, X-linked 1 NXF3 Xq22-q23 nuclear RNA export factor 3 FLJ10097 Xq22.1-q22.3 hypothetical protein FLJ10097 MGC45400 Xq22.2 hypothetical protein MGC45400 LOC340543 Xq22.2 similar to hypothetical protein MGC15737 DJ79P11.1 Xq22 X-linked protein MGC23947 Xq22.1 hypothetical protein MGC23947 LOC51186 Xq22.2 pp21 homolog NGFRAP1 Xq22.1 nerve growth factor receptor (TNFRSF16) associated protein 1 RAB40A Xq22.1 RAB40A, member RAS oncogene family FLJ21174 Xq22.2 hypothetical protein FLJ21174 MGC15737 Xq22.2 hypothetical protein MGC15737 TCEAL1 Xq22.1 transcription elongation factor A (SII)-like 1 LOC139779 Xq22.2 similar to hypothetical protein FLJ38101 MORF4L2 Xq22 mortality factor 4 like 2 MGC39655 Xq22.2 hypothetical protein MGC39655 PLP1 Xq22.2 proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) RAB9B Xq22.1-q22.3 RAB9B, member RAS oncogene family LOC347393 Xq22.2 similar to bA370B6.1 (similar to histone H2B) LOC170242 Xq22.2 similar to mitochondrial carrier triple repeat 1 MGC39900 Xq22.2 hypothetical protein MGC39900 LOC158983 Xq22.2 hypothetical protein LOC158983 LOC286436 Xq22.2 hypothetical protein LOC286436 LOC392512 X similar to histone H2B-related protein LOC392513 X similar to mitochondrial carrier triple repeat 1 LOC392514 X similar to cU46H11.1 (novel protein) LOC139231 Xq22.2 hypothetical protein BC016683 ESX1L Xq22.1-q22.3 extraembryonic, spermatogenesis, homeobox 1-like
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 862 - 125 - Alvarez (2005)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas   highly
    Nervousbrainhindbraincerebellum  
     brainforebraincerebral lobetemporal lobe 
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Rex3
    intraspecies paralog to BEX2
    Homologene
    FAMILY
  • BEX family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • with NGFRAP1 interact with NGFR and modulate nerve growth factor (NGF) signaling through nuclear factor-kappaB (NF-kappaB) to regulate cell cycle, apoptosis, and differentiation in neural tissues (Naderi 2007)
  • epigenetic inactivation of BEX1 supports its role as a candidate tumour suppressor gene in intracranial ependymoma
  • while BEX1 and NGFRAP1 act as tumor suppressors, BEX2 seems to act as an oncogene
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind to NGFR intracellular domain and acts as a link between neurotrophin signaling, the cell cycle, and neuronal differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    is lost in a subgroup of patients with acute myeloid leukemia (AML) and chronic myeloid leukemia (CML)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS