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FLASH GENE
Symbol BET1L contributors: mct - updated : 22-11-2018
HGNC name blocked early in transport 1 homolog (S. cerevisiae) like
HGNC id 19348
Location 11p15.5      Physical location : 202.923 - 207.422
Synonym name
  • golgi SNARE 15 kDa protein
  • vesicle transport protein GOS15
  • golgi integral membrane protein 3
  • Synonym symbol(s) GS15, BET1L1, HSPC197, GOLIM3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE antisens
    text antisense to RIC-8 over 52 bp
    STRUCTURE 4.45 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2830 - 111 - 2013 23604678
    3 - 2971 - 102 - 2013 23604678
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer complex
    HOMOLOGY
    interspecies homolog to murine Bet1l
    Homologene
    FAMILY
    CATEGORY receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text BET1L is found in the medial cisternae of the Golgi apparatus
    basic FUNCTION
  • may be involved in both ER-to-Golgi and intra Golgi transport
  • essential role of GS15 in the Golgi apparatus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component form a complex with three other SNAREs (syntaxin 5, GS28, and Ykt6)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to Uterine fibroid (UFs)
  • Variant & Polymorphism SNP
  • rs2280543, increase risk for UF
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS