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FLASH GENE
Symbol BEST4 contributors: npt/ - updated : 20-09-2006
HGNC name bestrophin 4
HGNC id 17106
Location 1p34.1      Physical location : 45.249.258 - 45.253.426
Synonym name
  • bestrophin 4
  • Best vitelliform macular dystrophy like 2
  • vitelliform macular dystrophy 2-like 2
  • Synonym symbol(s) RP11-269F19.5, MGC126872, VMD2L2
    DNA
    TYPE functioning gene
    STRUCTURE 4.17 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2096 53 473 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon predominantly
    Endocrinepancreas    
    Reproductivefemale systemuteruscervix  
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text brain, spinal cord, retina, lung, trachea, testis, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • unique C terminus, transmembrane helix
  • HOMOLOGY
    Homologene
    FAMILY
  • RFP-TM family
  • bestrophin family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • being able to form Ca-activated Cl channels in heterologous systems
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS