Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BEND3 contributors: mct - updated : 24-12-2012
HGNC name BEN domain containing 3
HGNC id 23040
Location 6q21      Physical location : 107.386.384 - 107.435.636
Synonym name hypothetical protein LOC57673
Synonym symbol(s) KIAA1553, RP11-59I9.2
DNA
TYPE functioning gene
STRUCTURE 49.25 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
Map cen - BEND3 - D6S268 - D6S1635 - qter
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 6660 94.34 828 - 2011 21914818
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a quadruple BEN domain
  • conjugated PhosphoP , sumoylated
    HOMOLOGY
    interspecies homolog to murine Bend3 (91.2 pc)
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    text
  • associates with the locus only when it is heterochromatic and dissociates upon activation of transcription
  • basic FUNCTION
  • involved in transcriptional repression through its interaction with histone deacetylases and SALL4, a transcription repressor
  • SUMOylated and such modifications are essential for its role in transcriptional repression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS