protein
| BCL2-binding disrupt BECN1 autophagy function, by inhibiting the formation of the BECN1/PI3K complex |
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interacting with APG7L for autophagic death (induced by CASP8 inhibition) |
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interacting with GOPC and GRID2 |
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physically bind to survivin (BIRC5)  |
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can interact with the anti-apoptotic protein BCL2 and this interaction impacts on the activity of both apoptosis and autophagy |
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RELA target gene and present evidence that blockage of RELA signaling leads to a decrease in BECN1 transcription  |
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interacts with PINK1 and enhances autophagy  |
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interaction between BECN1 and BIRC5 affects the sensitivity of human glioma cells to TNFSF10-induced apoptosis  |
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interaction with HRAS (HRAS-induced expression of PMAIP1 and Beclin-1 promotes autophagic cell death)  |
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interacting with USP13 and USP10 (BECN1 controls the protein stabilities of USP10 and USP13 by regulating their deubiquitinating activities)  |
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TAB2 and TAB3 bind to BECN1 and colocalize in the cytoplasm  |
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BECN1 cooperates with RAC1  |
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SLAMF1 interacts with the class III PIK3C3 in a complex with BECN1 and UVRAG  |
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ATG14 directly interacts with BECN1 through its coiled-coil domain and enhances phosphatidylinositol 3-phosphate kinase class III (PI3KC3) activity to induce autophagosome membrane nucleation  |
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actin filaments colocalized with ATG14, BECN1/Beclin1 and PtdIns3P-rich structures, and some of them have a typical omegasome shape stained with the double FYVE domain or ZFYVE1  |
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EMC6 interacted with both RAB5A and BECN1/Beclin 1 and colocalized with the omegasome marker ZFYVE1/DFCP1  |
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spliced XBP1 translocates into the nucleus and binds as homodimer or heterodimer to the BECN1 gene promoter, leading to BECN1 transcription  |
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induces autophagy by disrupting the association between BCL2 and BECN1  |
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AMPK directly phosphorylates PIK3C3 and BECN1 to regulate non- and pro-autophagic PIK3C3 complexes, respectively  |
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ATG14 is critical in controlling an autophagy-dependent phosphorylation of BECN1  |
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WASH1 can suppress BECN1 ubiquitination to inactivate PIK3C3 activity leading to suppression of autophagy  |
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EGFR suppression of BECN1 may contribute to tumor progression in lung cancer  |
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ligand-dependent EGFR activation leads to the interaction of EGFR and BECN1, which likely occurs primarily in endosomes  |
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deubiquitylated RALB promotes the assembly of the RALB-EXOC8-BECN1 complexes driving autophagosome formation  |
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PRNP interacts with BECN1 to recruit the PIK3C3 complex into lipid rafts and thus activates autophagy in response to Abeta42, defining a novel role of PRNP in the regulation of autophagy  |
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RASD2 robustly binds the autophagy regulator BECN1, decreasing its inhibitory interaction with BCL2 independent of MAPK8 signaling  |
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BECN1 interacts with the Parkinson disease-related protein PARK2 (BECN1 interacts with PARK2 and regulates PARK2 translocation to mitochondria as well as PARK2-induced mitophagy prior to autophagosome formation)  |
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WASH1 is a new interactor of BECN1 and present in the BECN1-PIK3C3 complex with AMBRA1  |
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DACT1 enhances the ATG14-BECN1-PIK3C3 complex formation and PIK3C3 kinase activity  |
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NRBF2-BECN1 interaction required the N terminus of NRBF2  |
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NRBF2 may interact with the ATG14-containing BECN1-PIK3C3 protein complex to modulate protein-protein interactions within the complex, leading to suppression of PIK3C3 activity, autophagosome biogenesis, and autophagic flux  |
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XIAP and BIRC2 induce autophagy by upregulating the transcription of BECN1, an essential autophagy gene  |
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SMAD2 is the major transcriptional regulator of autophagy that targets beclin1 (BECN1) gene expression  |
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GADD45A inhibits autophagy via impairing the BECN1-PIK3C3 complex formation  |
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dual functions of the USP19-BECN1 axis by balancing autophagy and the production of type IIFNs  |
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ERBB2 interacts with BECN1 in breast cancer cells and inhibits autophagy  |
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RNF216 regulates the migration of GNRH1 neuron by suppressing BECN1 mediated autophagy, suggesting a potential contribution of autophagy to the hypogonadotropic hypogonadism  |
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USP36 is regulator for the PRKN-dependent mitophagy at least in part via the BECN1-ATG14 pathway  |