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FLASH GENE

Symbol

BCYRN1

contributors: mct - updated : 29-06-2007

HGNC name	brain cytoplasmic RNA 1, Bc1 analog (mouse)
HGNC id	1022

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2p21-p16      Physical location : 70.430.034 - 70.948.962
Synonym symbol(s)	BC200RNA, BC200alpha, BC1

DNA

TYPE	functioning gene
STRUCTURE	0.00 kb     1 Exon(s)    1 Copie(s)

regulatory sequence

MAPPING

cloned

Y

linked

Y

status

provisional

Map	pter - D2S177 - D2S119 - D2S1736 - BCYRN1 - D2S357 - cen
Authors	Basile (98)

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon hypothalamus       brain forebrain cerebral cortex     Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial sensory visual

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 5-prime domain derived from Alu elements that contains consensus elements A and B of the split RNA polymerase III promoter and signal recognition particle motifs
	a central A-rich region, central domain with a single-stranded homopolymeric A segment of 22 nucleotides
	a unique 3-prime sequence containing 42 nucleotides

HOMOLOGY

interspecies

ortholog to murine Bc1

Homologene

FAMILY

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION
text	neuropil areas of the retina
	localizes to synaptodendritic domains

basic FUNCTION	micro RNA regulating dentritic protein synthesis
	determine the specificity of FMR1 function by linking the regulated mRNAs and FMR1
	translational repressor that have been implicated in the modulation of postsynaptic protein repertoires in neurons, as FMR1 (but BCYRN1 and FMR1 operate at different levels in the translation pathway)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of a ribonucleoprotein complex

INTERACTION

DNA

RNA

small molecule

protein

potential analog of Bc1, associated with FMR1 for regulating the translation of specific mRNA at synapses

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS