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FLASH GENE
Symbol BCO2 contributors: mct - updated : 30-03-2015
HGNC name beta-carotene oxygenase 2
HGNC id 18503
Location 11q23.1      Physical location : 112.046.207 - 112.089.647
Synonym name
  • putative b,b-carotene-9',10'-dioxygenase
  • beta-carotene dioxygenase 2
  • Synonym symbol(s) B-DIOX-II, BCDO2, FLJ34464
    EC.number 1.14.99.-/1.13.11.71
    DNA
    TYPE functioning gene
    STRUCTURE 43.44 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2925 - 579 - -
    10 - 2706 - 506 - -
    12 - 2813 - 545 - -
    12 - 2795 - 539 - -
    11 - 2608 - 474 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Visualeyeretina    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Bcdo2
    homolog to Drosophila RPE65
    homolog to C.elegans F53C3.12
    Homologene
    FAMILY
  • carotenoid oxygenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • catalysing oxydation of beta-carotene by incorporation of two atoms of oxygen from molecular oxygen
  • mitochondrial carotenoid-oxygenase with broad substrate specificity
  • is a crucial protective component against oxidative stress and a mitochondrial carotenoid scavenger and a gatekeeper of the intrinsic apoptotic pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism vitamin
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Bco2 knockout mice, unlike WT mice, accumulate zeaxanthin in their retinas
  • in Bcdo2-deficient mice, carotenoid homeostasis was abrogated, and carotenoids accumulated in several tissues