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FLASH GENE

Symbol

BCMO1

contributors: - updated : 30-03-2004

HGNC name	beta-carotene 15,15'-monooxygenase 1
HGNC id	13815

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q23.2      Physical location : 81.272.295 - 81.324.747
Synonym name	beta-carotene 15, 15'-dioxygenase
Synonym symbol(s)	BCDO1, BCO, BCDO, BCMO
EC.number	1.14.99.36

DNA

TYPE	functioning gene
STRUCTURE	52.45 kb     11 Exon(s)

regulatory sequence

Promoter (TATA box)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017429 11 - 2446 NP_059125 - 547 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain         Reproductive male system testis       Urinary kidney         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining retinal pigment epithelium (RPE)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C terminal 20AA

HOMOLOGY

interspecies

homolog to murine Bcdo

Homologene

FAMILY

carotenoid oxygenase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION

cleaving bda-carotene into two molecules of retinal key enzyme in beta carotene metabolism to vitamin A

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

vitamin

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS