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FLASH GENE
Symbol BCL9 contributors: - updated : 28-02-2007
HGNC name B-cell CLL/lymphoma 9
HGNC id 1008
Location 1q21      Physical location : 147.013.181 - 147.098.013
DNA
TYPE functioning gene
STRUCTURE 84.00 kb     10 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
RBM8A 1q12 RNA binding motif protein 8A GNRHR2 1q12 gonadotropin-releasing hormone (type 2) receptor 2 PEX11B 1q21.2 peroxisomal biogenesis factor 11B ITGA10 1q21 integrin, alpha 10 FLJ25124 1q21.2 hypothetical protein FLJ25124 PIAS3 1q21 hypothetical protein FLJ25124 RPC62 1q21.2 polymerase (RNA) III (DNA directed) (62kD) ZNF364 1q21.1 zinc finger protein 364 CD160 1q21.1 CD160 antigen PDZK1 1q21 PDZ domain containing 1 LOC388678 1 LOC388678 LOC391090 1 hypothetical gene supported by AB007923; AL833273 LOC200030 1q21.2 hypothetical protein LOC200030 LOC391091 1 similar to Profilin I LOC91632 1q21.2 similar to MGC5244 protein LOC388679 1 LOC388679 LOC388680 1 LOC388680 LOC388681 1 similar to KIAA0454 protein LOC388682 1 hypothetical gene supported by BC001289; NM_003142 PRKAB2 1q21 protein kinase, AMP-activated, beta 2 non-catalytic subunit LOC388683 1 hypothetical gene supported by NM_005313 FMO5 1q21.1 flavin containing monooxygenase 5 CHD1L 1q12 chromodomain helicase DNA binding protein 1-like BCL9 1q21 B-cell CLL/lymphoma 9 ACP6 1q21 lysophosphatidic acid phosphatase GJA5 1q21.1 gap junction protein, alpha 5, 40kDa (connexin 40) LOC391092 1 similar to Hypothetical protein DJ845O24.1 GJA8 1q21.1 gap junction protein, alpha 8, 50kDa (connexin 50) LOC388684 1 LOC388684 LOC388685 1 similar to hypothetical protein FLJ21308 COAS2 1q21.3 cyclophilin-LC DJ328E19.C1.1 1q12-1q21.2 hypothetical protein DJ328E19.C1.1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 6278 149 1426 - Willis
- - splicing 4200 - - ubiquitous Willis
- - splicing 1600 - - thymus, spleen, small intestine Willis
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousnervecranial nerve   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • large proline-rich protein containing a potential nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies ortholog to murine Bcl9
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in translocation t(1;14) and t(1;22)
  • involved in signal transduction through the Wnt pathway, promoted beta-catenin's transcriptional activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    Wnt receptor signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PYGO1
  • PYGO2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    B-cell malignancies with abnormalities of chr 1q21
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS