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FLASH GENE
Symbol BCL6B contributors: mct - updated : 25-01-2014
HGNC name B-cell CLL/lymphoma 6, member B (zinc finger protein)
HGNC id 1002
Location 17p13.1      Physical location : 6.926.368 - 6.932.961
Synonym name
  • BCL6 associated zinc finger protein
  • zinc finger protein 62
  • Synonym symbol(s) BAZF, ZNF62, ZBTB28
    DNA
    TYPE functioning gene
    STRUCTURE 7.24 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   ALU   long interspersed repetitive elements
    MAPPING cloned Y linked N status provisional
    Physical map
    HSXIAPAF1 17p13.2 XIAP associated factor-1 MGC35179 17p13.2 hypothetical protein MGC35179 TEKT1 17p13.2 tektin 1 ALOX12P2 17p13.1 arachidonate 12-lipoxygenase pseudogene 2 ALOX12 17p13.1 arachidonate 12-lipoxygenase LOC388328 17 LOC388328 MGC49942 17p13.2 hypothetical protein MGC49942 BCL6B 17p13.1 B-cell CLL/lymphoma 6, member B (zinc finger protein) LOC201232 SLC16A11 17p13.2 solute carrier family 16 (monocarboxylic acid transporters), member 11 CLECSF13 2p13.3 likely ortholog of mouse C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 13 ASGR2 17p13.1 asialoglycoprotein receptor 2 ASGR1 17p12 asialoglycoprotein receptor 1 DLG4 17p13.1 discs, large (Drosophila) homolog 4 ACADVL 17p13.1 acyl-Coenzyme A dehydrogenase, very long chain DVL2 17p13.2 dishevelled, dsh homolog 2 (Drosophila) MGC2941 17p13.2 hypothetical protein MGC2941 GABARAP 17p13.1 GABA(A) receptor-associated protein DULLARD 17p13 dullard homolog (Xenopus laevis) DERP6 17p13.2 S-phase 2 protein CLDN7 17p13.1 claudin 7 SLC2A4 17p13.1 solute carrier family 2 (facilitated glucose transporter), member 4 YBX2 17p11.2-p13.1 germ cell specific Y-box binding protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3544 51.6 480 - Sakashita (2002)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage immature B cell lineage
    cell lines erythroleukemia cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • BTB/POZ domain
  • five repeats of the Krüppel-like zinc finger motif at the N and C terminus
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Bcl6b
    intraspecies homolog to BCL6
    Homologene
    FAMILY BTB/POZ family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • repressor, having protein binding activity
  • regulating differentiation in stages or lineages different from those regulated by BCL6
  • required for the enhanced magnitude of the secondary response of memory CD8(+) T cells
  • BCL6 and BCL6B regulate hematopoietic progenitor cells (HPC) homeostasis by an indirect pathway involving CD8 T cell
  • mediates KDR and Notch cross-signaling in angiogenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • FGF2 depends on MAP2K1 signaling to drive spermatogonial stem cell (SSC) self-renewal via upregulation of the ETV5 and BCL6B genes
  • PRKD2, mediated BCL6B gene expression by VEGFA stimulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • BCL6B methylation may serve as a novel potential non-invasive plasma biomarker for the detection of gastric cancer
  • Therapy target
    ANIMAL & CELL MODELS