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FLASH GENE
Symbol BCL3 contributors: mct - updated : 07-07-2010
HGNC name B-cell CLL/lymphoma 3
HGNC id 998
Location 19q13.32      Physical location : 45.251.977 - 45.263.300
Synonym name
  • B-cell lymphoma 3-encoded protein
  • protein Bcl-3
  • chronic lymphatic leukemia protein
  • proto-oncogene BCL3
  • Synonym symbol(s) BCL4, D19S37, BCL-3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 11.32 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Physical map
    ZNF233 19q13.32 zinc finger protein 233 ZNF235 19q13.3 zinc finger protein 235 MRPS15P2 19q13.32 zinc finger protein 235 ZNF228 19q13.2 zinc finger protein 228 LOC388549 19 LOC388549 ZNF285  zinc finger protein 285 ZNF229 19q13.2 zinc finger protein 229 LOC147711 19q13.32 similar to zinc finger protein 285 ZNF180 19q13.1-q13.3 zinc finger protein 180 (HHZ168) UNQ9366 19q13.32 GPAD9366 LOC388550 19 similar to CEACAM5 protein LOC390941 19 LOC390941 LOC147710 19q13.32 hypothetical LOC147710 PVR 19q13.2 poliovirus receptor CEAL1 19q13.32 carcinoembryonic antigen-like 1 LOC388551 19 similar to carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) BCL3 19q13.2 B-cell CLL/lymphoma 3 CBLC 19q13.2-q13.3 Cas-Br-M (murine) ecotropic retroviral transforming sequence c LU 19q12-q13 Lutheran blood group (Auberger b antigen included) PVRL2 19q13.2-q13.4 poliovirus receptor-related 2 (herpesvirus entry mediator B) TOMM40 19q13 translocase of outer mitochondrial membrane 40 homolog (yeast) APOE 19q13.2 apolipoprotein E APOC1 19q13.2 apolipoprotein C-I APOC4 19q13.2 apolipoprotein C-IV APOC2 19q13.2 apolipoprotein C-II CLPTM1 19q13.2 cleft lip and palate associated transmembrane protein 1 RELB 19q13.32 v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian) SFRS16 19q13.3 splicing factor, arginine/serine-rich 16 (suppressor-of-white-apricot homolog, Drosophila) ZNF342 19q13.32 zinc finger protein 342 GEMIN7 19q13.32 gem (nuclear organelle) associated protein 7 EIF5AP3 19q13.2 eukaryotic translation initiation factor 5A pseudogene 3 LOC284352 19q13.32 hypothetical protein LOC284352 FLJ33600 19q13.32 FLJ33600 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1864 - 454 - 2010 20226764
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     salivary gland   predominantly
    Lymphoid/Immunespleen    
    Reproductivefemale systemovary   
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain is an essential region for the degradation, transcriptional activity, and oncogenic potential of TBL1XR1
  • seven ANK repeats, an ankyrin repeat domain, which is known to bind several nuclear proteins (for interaction with IRS3L)
  • HOMOLOGY
    interspecies ortholog to murine Bcl3
    Homologene
    FAMILY
    CATEGORY regulatory , protooncogene , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • inhibitor of REL/NFKB transcription factors
  • regulator of development differentiation apoptosis
  • functions as a repressor of HTLV-1 LTR-mediated transcription through interactions with CRTC3
  • involved in the regulation of CRE-mediated transcription through its association with CRTC3
  • synergize with PPARGC1A to coactivate ESRRA
  • cytokine-stimulated transcriptional regulator, that is an ESRRA coactivator
  • potential oncogenic role for BCL3 in mutiple myeloma
  • CELLULAR PROCESS cell life, differentiation
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • ESRRA, PPARGC1A, and BCL3 form a complex on an ESRRA-responsive element within the pyruvate dehydrogenase kinase 4 gene promoter in cardiac myocytes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • N4BP2
  • COPS5
  • interacting with CRTC3 through the ankyrin repeat domain of BCL3
  • cooperativity between BCL3 and PPARGC1A may serve as a point of convergence on nuclear receptor targets to direct programs orchestrating inflammatory and energy metabolism responses in heart and other tissues
  • interact tightly with the NF-KB p50 homodimer (Kabuta 2010)
  • interacting with CTBP1 (required for the ability of BCL3 to repress gene transcription, CTBP1 is also required for the oncogenic potential of BCL3 and for its ability to inhibit UV-mediated cell apoptosis in keratinocytes)
  • cell & other
    REGULATION
    activated by by phosphorylation
    CNTN2 (upregulation that may help to mediate these effects of CNTN2 to promote cell proliferation)
    induced by IL6 via STAT3 binding to intronic enhancer HS4 and represses its own transcription
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    in chronic lymphocytic leukemia and non Hodgkin lymphoma in t(14;19)(q32-q13)
    constitutional     --over  
    increases apoptosis
    tumoral     --over  
    in human myeloma cells is associated with increased proliferation and inferior prognosis
    Susceptibility to Crohn disease
    Variant & Polymorphism SNP
  • rs2927488 in BCL3 significantly associated with Crohn disease (Pubmed 20601676)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS