Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BCL2L2 contributors: mct - updated : 03-12-2014
HGNC name BCL2-like 2
HGNC id 995
Location 14q11.2      Physical location : 23.776.011 - 23.780.966
Synonym name
  • apoptosis regulator BCL-W
  • protein phosphatase 1, regulatory subunit 51
  • Synonym symbol(s) KIAA00271, BCLW, BCL-W, BCL2-L-2, PPP1R51
    DNA
    TYPE functioning gene
    STRUCTURE 4.99 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    Physical map
    MRPL52 14q11.2 mitochondrial ribosomal protein L52 MMP14 14q11.2 matrix metalloproteinase 14 (membrane-inserted) LRP10 14q11.2 low density lipoprotein receptor-related protein 10 FLJ38964 14q11.2 hypothetical protein FLJ38964 RNPC4 14q11.2 RNA-binding region (RNP1, RRM) containing 4 SKB1 14q11.2-q21 SKB1 homolog (S. pombe) C14orf94 14q11.1 chromosome 14 open reading frame 94 JUB 14q11.2 jub, ajuba homolog (Xenopus laevis) C14orf93 14q11.1 chromosome 14 open reading frame 93 PSMB5 14q11.2 proteasome (prosome, macropain) subunit, beta type, 5 LOC122706 14q11.2 similar to RIKEN cDNA 5830406J20 CDH24 14q11.2 cadherin-like 24 ACINUS 14q11.2 apoptotic chromatin condensation inducer in the nucleus C14orf119 14q11.2 chromosome 14 open reading frame 119 CEBPE 14q11.2 CCAAT/enhancer binding protein (C/EBP), epsilon SLC7A8 14q11.2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 RPL39P2 14 ribosomal protein L39 pseudogene 2 HMGN2P 14 high-mobility group nucleosomal binding domain 2 pseudogene KIAA1443 14q11.2 KIAA1443 LOC90673 BCL2L2 14q11.2-q12 BCL2-like 2 PABPN1 14q11.2-q13 poly(A) binding protein, nuclear 1 SLC22A17 14q11.2 solute carrier family 22 (organic cation transporter), member 17 EFS 14q11.2-q12 embryonal Fyn-associated substrate IL17E 14q11.2 interleukin 17E CKLFSF5 14q11.2 chemokine-like factor super family 5 MYH6 14q11.2 myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) MYH7 14q11.2 myosin, heavy polypeptide 7, cardiac muscle, beta C14orf120 14q11.2 chromosome 14 open reading frame 120 ZFHX2 14q11.2 zinc finger homeobox 2 ZNF409 14q11.2 zinc finger protein 409 THTPA 14q11.2 thiamine triphosphatase AP1G2 14q11.2 adaptor-related protein complex 1, gamma 2 subunit JPHL1 14q11 junctophilin like 1 LOC387974 14 LOC387974 DHRS2 14q11.2 dehydrogenase/reductase (SDR family) member 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2130 - 333 - 2003 12660157
    4 - 3521 - 193 - 2003 12660157
    4 - 3576 - 193 - 2003 12660157
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage lymphoid and myeloid cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • from the N terminal, three BCL2 homology domains, BH3, BH1, BH2
  • bh4 motif seems to be involved in the anti-apoptotic function
  • a C terminal membrane anchoring segment
  • secondary structure eight alpha helices
    HOMOLOGY
    Homologene
    FAMILY BCL-2 family of anti-apoptotic proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    text
  • evidence of BCL2L2 localization in the growth cones of differentiating neuronal cells
  • basic FUNCTION
  • promotes cell survival
  • mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX
  • essential for the regulation of cellular survival, and up-regulated in different human tumors, such as gastric and colorectal carcinomas
  • not only promotes neuronal survival, but also neuronal differentiation
  • is required for the viability of small fiber nociceptive sensory neurons
  • functions of BCL2L2 and BAX are mimicked by other pro-survival and pro-apoptotic members, such as BCL2L1 and BAK, respectively
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • 17beta-estradiol (E2) upregulates expression of antiapoptotic BCL2L2 and downregulates expression of proapoptotic BCL2L11 in an estrogen receptor (ER)-dependent manner
  • BCL2L2 and GRID2 might interact genetically to regulate mitochondria, autophagy, and neuronal function
  • AKT1 may induce anti-apoptotic signals at least in part through the regulation of the amount and activity of BCL2L2
  • upon stress, NEUROD6 promotes colocalization of BCL2L2 with mitochondria and endoplasmic reticulum
  • interacts with BAX and suppresses the CASP6 apoptotic cascade that fosters axonal degeneration
  • cell & other
    REGULATION
    induced by pericytes that induced the antiapoptotic protein BCL2L2 in tumor endothelial cells (ECs)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Bclw(-/-) mice demonstrate an adult-onset progressive decline in thermosensation and a decrease in nociceptor innervation of the epidermis