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FLASH GENE
Symbol BCL2L14 contributors: mct - updated : 09-04-2020
HGNC name BCL2-like 14 (apoptosis facilitator)
HGNC id 16657
Location 12p13.2      Physical location : 12.223.877 - 12.252.625
Synonym name
  • BCL-gonad
  • apoptosis regulator BCL-G
  • testicular tissue protein Li 26
  • Synonym symbol(s) ABCP, WHITE2, MXR, BCRP, MXR1, ABC15, BCLG
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 49.85 kb     6 Exon(s)
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    Map pter - ETV6 - D12S89 - D12S98 - BCL2L14 - LRP6 - LOH12CR3 - LOH12CR2 - D125358 - DUSP16 - CREBL2 - GPR19 - CDKN1B - cen
    Authors Montpetit (02)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1886 - 327 highly expressed in healthy gut tissue 2008 18006276
  • BCLG-L or V1
  • BH3 and BH2 domain
  • distributed throughout the cytosol
  • its mRNA levels decreased in colorectal cancer
  • 6 splicing 2039 - 252 in testis, and highly expressed in healthy gut tissue 2008 18006276
  • BCLG-S or V2
  • BH3 domain
  • predominantly localized to cytosolic organelles
  • its mRNA levels decreased in active inflammatory bowel diseases
  • - - 1176 - 276 - 2008 18006276
    6 - 1897 - 327 - 2008 18006276
    8 - 2117 - 327 - 2008 18006276
    7 - 1844 - 327 - 2008 18006276
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   moderately
    Reproductivemale systemprostate  moderately
     male systemtestis  highly
    Respiratorylung   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four conserved BCL2 homology (BH) domains
  • BH3 domain
  • HOMOLOGY
    Homologene
    FAMILY BCL2 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • acting as anti- or pro-apoptotic regulator involved in a wide variety of cellular activities
  • COPS5 and BCL2L14 co-expression synergistically induces apoptosis
  • FAU, BCLG and MELK, are crucially important in breast cancer
  • most probably does not function in the classical stress-induced apoptosis pathway, but rather has a role in protein trafficking inside the cell
  • apoptosis-enhancing effect of FAU-BCL2L14 is due in part to down-regulation of PTGS2 activation in macrophages
  • may be involved in shaping immune responses in the human gut in health and disease states through regulation of chemokine secretion rather than intestinal apoptosis
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CD3D/CD28-inducible FAU/BCL2L14 complex may be involved in the regulation of T cell function and survival
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • COPS5 is involved in the regulation of mitochondrial apoptotic pathway through specific interaction with BCL2L14
  • FAU modifies apoptosis-controller BCL2L14, which is also a key target for candidate oncoprotein maternal embryonic leucine zipper kinase (MELK)
  • pro-apoptotic activity of the FAU/BCL2L14 pathway offers an attractive explanation for the putative tumour suppressor role of FAU
  • interacts specifically with proteins of the transport particle protein complex
  • FAU covalently binds to intracellular pro-apoptotic protein BCL2L14 and regulates apoptosis in macrophages
  • BCL2L14 genes may play an important role in the GSK3B-mediated osteoblast apoptosis process
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in advanced prostate carcinoma
    tumoral     --over  
    in Medullary breast carcinoma (MBC)
    constitutional     --over  
    may contribute to the aberrant CD4+ T cell apoptosis which causes an inappropriate immune response and impaired homeostasis in SLE (systemic lupus erythematosus)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker attractive target for improvements in breast cancer risk prediction and prognosis
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    attractive target for improvements in breast cancer therapy
    ANIMAL & CELL MODELS