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FLASH GENE
Symbol BCL2A1 contributors: npt/ - updated : 20-04-2007
HGNC name BCL2-related protein A1
HGNC id 991
Location 15q25.1      Physical location : 80.253.232 - 80.263.643
Synonym name
  • Bcl-2-like protein 5
  • hemopoietic-specific early response protein
  • protein BFL-1
  • protein GRS
  • hematopoietic BCL2-related protein A1
  • Synonym symbol(s) GRS, BFL1, HBPA1, BCL2L5, ACC-1, ACC-2, BFL-1
    DNA
    TYPE functioning gene
    STRUCTURE 10.41 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    text structure
  • an NFKappa B site responsible
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 955 - 163 - -
    2 - 899 - 175 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  lowly
     stomach   moderately
    Lymphoid/Immunelymph node   highly
     spleen   highly
    Reproductivemale systemtestis  lowly
    Respiratorylung   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    Lymphoid    
    Muscularsmooth   
    cell lineage
    cell lines hematopoietic malignancies and melanoma
    fluid/secretion predominantly in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • two Bcl2 homology domains BH1 and BH2
  • C-terminal end of BCL2A1 is important for anchoring BCL2A1 to the mitochondria due to GFP-BCL2A1 being associated to the mitochondria, whereas GFP-BCL2A1, devoid of its C-terminal tail, also localizes in the cytosol (Brien 2009)
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Bcl2a1 (76.4 pc)
    homolog to murine Bcl2a1d (72.7 pc)
    intraspecies homolog to BCL2
    Homologene
    FAMILY
  • BCL-2 protein family of apoptosis regulators
  • CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text localizes to the mitochondria (Brien 2009)
    basic FUNCTION
  • retarding apoptosis induced by IL-3 deprivation
  • may function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection
  • reducing the release of pro-apoptolic cytochrome C from mitochondria and blocking caspase activation
  • required for mitochondrial viability and function
  • cytoprotective function
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    text apoptosis inhibitor,antipathogen response
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by NF Kappa B in response to inflammatory mediators
    GM-CSF, CD40, phorbol ester and inflammatory cytokine like TNF alpha and IL-1 beta
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target in the treatment of allergic diseases
    ANIMAL & CELL MODELS
    Bcl2a1 knock out mice (Xiang, 2001)