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FLASH GENE
Symbol BCCIP contributors: mct/npt - updated : 16-12-2009
HGNC name BRCA2 and CDKN1A interacting protein
HGNC id 978
Location 10q26.2      Physical location : 127.512.103 - 127.542.263
Synonym name
  • protein TOK-1
  • cdk inhibitor p21 binding protein
  • P21- and CDK-associated protein 1
  • Synonym symbol(s) TOK-1, BCCIPalpha, TOK-1 alpha, TOK-1 beta
    DNA
    TYPE functioning gene
    STRUCTURE 30.16 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC340784 10q26.13 similar to NK-type homeobox LOC387716 10 similar to Hmx2 protein LOC387717 10 LOC387717 BUB3 10q26 BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) LOC390009 10 similar to 40S ribosomal protein S26 GPR26 10q26.2-q26.3 G protein-coupled receptor 26 DKFZp761H2121 10q26.13 hypothetical protein DKFZp761H2121 LOC119587 10q26.13 hypothetical protein LOC119587 GALNAC4S-6ST 10q26 hypothetical protein LOC119587 FLJ12616  hypothetical protein FLJ12616 LOC340735 10q26.2 similar to germ cell specific Y-box binding protein; contrin OAT 10q26 ornithine aminotransferase (gyrate atrophy) OATL3 10q26 ornithine aminotransferase-like 3 (pseudogene) LOC390010 10 similar to Sax-1 LHPP 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase KIAA0140 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase KIAA0157 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase ZRANB1 10q26.13 zinc finger, RAN-binding domain containing 1 CTBP2 21q21.3 C-terminal binding protein 2 MRPS21P6 10q26 mitochondrial ribosomal protein S21 pseudogene 6 LOC387718 10 hypothetical gene supported by AK131010; BC062717 LOC387719 10 LOC387719 EDRF1 10q26.2 erythroid differentiation-related factor 1 MMP21 10q26.3 matrix metalloproteinase 21 UROS 10q25.2-q26.3 uroporphyrinogen III synthase (congenital erythropoietic porphyria) BCCIP 10q26.1 BRCA2 and CDKN1A interacting protein DDX32 10q26.3 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32 FANK1 10q26.2 fibronectin type 3 and ankyrin repeat domains 1 ADAM12 10q26.3 a disintegrin and metalloproteinase domain 12 (meltrin alpha) FLJ32938 10q26.2 hypothetical protein FLJ32938 DOCK1 10q26.13-q26.3 dedicator of cyto-kinesis 1 LOC387720 10 hypothetical gene supported by AK127642 LOC338623 10q26.2 similar to hypothetical protein B130055A05 MGC32871 10q26.3 hypothetical protein MGC32871 PTPRE 10q26 protein tyrosine phosphatase, receptor type, E MKI67 10q25-qter antigen identified by monoclonal antibody Ki-67
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 1461 36.2 322 - Meng (2007), Lu (2005), Meng (2004)
  • also called BCCIPalpha
  • interacts with BRCA2
  • enhances the inhibitory activity of CDKN1A toward CDK2 and BCCIP alpha inhibits the growth of certain tumor cells
  • negatively regulated by MTDH
  • 7 splicing 1261 36 314 brain, heart, liver, pancreas, prostate, lung, kidney, bone marrow Meng (2007), Lu (2005), Meng (2004)
  • also called BCCIPbeta
  • interacts with BRCA2 and this interaction occurs in a region shared by BCCIPalpha and BCCIPbeta
  • binds to CDKN1A and inhibits cell growth
  • 7 splicing 2373 - 292 - Meng (2007), Liu J
    also called variant C
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivepharynx   highly
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscular    
    cell lineage
    cell lines
  • brain cancer
  • breast cancer
  • kidney cancer
  • colon cancer
  • fluid/secretion
    at STAGE
    cell cycle     cell cycle, G1, S
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • a N terminus acidic domain, sharing moderate homology with regions of calmodulin and M-calpain,
  • an internal conserved domain
  • HOMOLOGY
    Homologene
    FAMILY
  • BCP1 family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the regulation of CDK activity
  • regulates BRCA2 and RAD51 nuclear focus formation
  • plays a critical role in resolving spontaneous DNA damage
  • playing critical roles in homologous recombination regulation and the maintenance of genome stability
  • playing an essential role in the maintenance of genomic integrity (Meng 2007)
  • enhancing CDKN1A suppression activity towards CDK2, and BCCIP downregulation reduces CDKN1A expression by abrogating TP53 transcription activity (Fan 2009)
  • required for the nuclear localization of CDKN1A protein (Fan 2009)
  • playing a role in astrocytic tumorigenesis, and lack of BCCIP may be used as a marker for astrocytomas (Liu 2009)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to BRCA2 (both BCCIPalpha and BCCIPbeta), CDKN1A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    leads to chromosomal polyploidization, centrosome amplification and abnormal mitotic spindle formation (Meng 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS