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FLASH GENE
Symbol BCAT1 contributors: mct/npt/pgu - updated : 10-03-2010
HGNC name branched chain aminotransferase 1, cytosolic
HGNC id 976
Location 12p12.1      Physical location : 24.962.957 - 25.102.393
Synonym name
  • protein ECA39
  • placental protein 18
  • branched-chain-amino-acid aminotransferase, cytosolic
    • Synonym symbol(s) BCT1, ECA39, MECA39, Bcatc, PP18, PNAS-121, DKFZp686E12175
    EC.number 2.6.1.42
    DNA
    TYPE functioning gene
    STRUCTURE 138.03 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 8282 - 386 - 2008 18419134
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiensAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiensAdult
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text during embryogenesis, in the brain and kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • CXXC motif with thiols groups (C335 and C338 directly involved in the reversible redox regulation of BATC1)
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • class-IV pyridoxal-phosphate-dependent aminotransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzes the transamination of the essential branched chain amino acids (leucine, isoleucine and valine) with alpha-ketoglutarate
  • may play a certain role in nasopharyngeal carcinoma development
  • having redox mediated associations with several neuronal proteins involved in G-protein cell signaling, indicating a novel role for in cellular redox control
  • BCAT1, BCAT2 are novel biomarkers for cytosolic and mitochondrial oxidative stress
  • a role in both glutamate production and glutamate release during excitation
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
    • protein
    cell & other
    REGULATION
    Other expression in the brain specifically regulated by BDNF in a time- and region-dependent fashion
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in C-Myc induced tumors such as Burkitt's lymphoma
    tumoral     --over  
    in nasopharyngeal carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS