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FLASH GENE
Symbol BCAS2 contributors: mct/npt - updated : 02-06-2015
HGNC name breast carcinoma amplified sequence 2
HGNC id 975
Location 1p13.2      Physical location : 115.110.182 - 115.124.265
Synonym name
  • DNA amplified in mammary carcinoma 1
  • spliceosome associated protein, amplified in breast cancer
  • Pre-mRNA-splicing factor SPF27
  • Synonym symbol(s) DAM1, SPF27, Snt309
    DNA
    TYPE functioning gene
    STRUCTURE 14.09 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    MAGI-3 1p12-p11.2 membrane-associated guanylate kinase-related (MAGI-3) PHTF1 1p13-p11 putative homeodomain transcription factor 1 FLJ11220 1p13.1 hypothetical protein FLJ11220 PTPN22 1p13.3-p13.1 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) LOC148280 1p13.1 hypothetical LOC148280 AP4B1 1p11.2 adaptor-related protein complex 4, beta 1 subunit DCLRE1B 1p11.2 DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) HIPK1 1p12 DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) HNOEL-iso 1p13.1 HNOEL-iso protein SYT6 1p13.1 synaptotagmin VI MRP63P1 1p13.1 mitochondrial ribosomal protein 63 pseudogene 1 LOC391067 1 LOC391067 TRIM33 1p13.1 tripartite motif-containing 33 LOC347675 1p13.1 eukaryotic translation initiation factor 2 beta-like pseudogene LOC339395 1p13.1 similar to Pyruvate kinase, M2 isozyme BCAS2 1p21-p13.3 breast carcinoma amplified sequence 2 FLJ37099 1p13.1 FLJ37099 protein AMPD1 1p13 adenosine monophosphate deaminase 1 (isoform M) NRAS 1p13.2 neuroblastoma RAS viral (v-ras) oncogene homolog D1S155E 1p22 NRAS-related gene FLJ21168 1p13.1 hypothetical protein FLJ21168 SYCP1 1p13 synaptonemal complex protein 1 TSHB 1p13 thyroid stimulating hormone, beta TSPAN-2 1p13.1 tetraspan 2 NGFB 1p13.1 nerve growth factor, beta polypeptide LOC391068 1 similar to mCAF1 protein VANGL1 1p11-p13.1 vang-like 1 (van gogh, Drosophila) LOC387624 1 hypothetical gene supported by NM_024062 CASQ2 1p13.3-p11 calsequestrin 2 (cardiac muscle)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1310 26.1 225 - 1999 1040356
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a central potential N glycosylation site
  • multiple N terminal potential phosphorylation sites
  • C-terminal coiled-coil domain binds directly to CDC5L and recruits PRPF19/PLRG1 to form a core complex for splicing in mammalian cells
  • HOMOLOGY
    interspecies homolog to C.elegans T12A2.7 protein,possibly
    Homologene
    FAMILY
  • SPF27 family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • spliceosome associated protein
  • estrogen receptor (ER) alpha interacting protein that might play an important role in breast cancer development by increasing the estrogen receptor's function
  • transcriptional coactivator of estrogen receptor
  • BCAS2/DAM1 complex has a preference for native tubulin over tubulin that is lacking its acidic C-terminal tail
  • function in RNA splicing, which affects cell viability
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • spliceosome subunit
  • BCAS2 can form a complex with AR and HSP90AB1, it may function with HSP90 to stabilise AR protein from being degraded by proteasome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacts with TP53 to reduce TP53 transcriptional activity by mildly but consistently decreasing TP53 protein in the absence of DNA damage
  • BCAS2 directly interacts with each component of the PRPF19/CDC5L complex core
  • BCAS2 and PRPF19 subunits of the PSO4 complex directly interact and colocalize with replication protein A (RPA1)
  • functions as a negative regulator of TP53
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in breast carcinoma
    tumoral     --over  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS