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FLASH GENE
Symbol BCAR3 contributors: mct - updated : 22-06-2016
HGNC name breast cancer anti-estrogen resistance 3
HGNC id 973
Location 1p22.1      Physical location : 94.027.350 - 94.147.385
Synonym name
  • novel SH2-containing protein 2
  • SH2 domain-containing protein 3B
  • Synonym symbol(s) NSP2, SH2D3B, KIAA0554, HGN
    DNA
    TYPE functioning gene
    STRUCTURE 120.03 kb     12 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3184 - 825 - 2007 17270363
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   moderately
     mouthtongue  moderately
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systembreastmammary gland moderately
     female systemplacenta  highly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective   moderately
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative SRC homology 2 (SH2) domain, interacting with Tyr789 of PTPRA, interaction required for PTPRA-BCAR3-PTPR1-SRC interaction and promotes the integrin-induced movement of BCAR3 and BCAR1 to focal adhesion-enriched fractions
  • a Ras-GEF domain, that binds to BCAR1
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Bcar3 (85.9 pc)
    homolog to murine Bcar3 (86.1 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • regulating cell growth and apoptosis in hormone-sensitive cells
  • may act as an adaptor protein
  • coupling activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells
  • acting as a guanyl-nucleotide exchange factor
  • involved in reponse to drug
  • implicated in the regulation of cell morphology, adhesion and migration
  • regulating SRC activity in the endogenous setting of breast cancer cells (Schuh 2010)
  • regulating the interaction between BCAR1 and SRC, qualitatively and quantitatively (Schuh 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • small GTPase mediated signal transduction
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BCAR1, NEDD9, PTK2 and PTPN1
  • is an activator of SRC and is a molecular linker of PTPRA and BCAR1 (
  • BCAR3 plays an important role in the signaling pathways of insulin leading to cell cycle progression and cytoskeleton reorganization, but not SLC2A4 translocation
  • cell & other
    REGULATION
    Other regulated by cellular adhesion to extracellular matrix proteins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    confering anti-estrogen resistance in breast cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS