Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BCAM contributors: mct - updated : 27-01-2015
HGNC name basal cell adhesion molecule (Lutheran blood group)
HGNC id 6722
Corresponding disease
LU Lutheran blood group
Location 19q13.32      Physical location : 45.312.337 - 45.324.677
Synonym name
  • basal cell adhesion molecule (Lu and Au blood groups)
  • F8/G253 antigen
  • glycoprotein 95kDa
  • B-cell adhesion molecule
  • Auberger B antigen
  • antigen identified by monoclonal antibody F8
  • glycoprotein 95kDa
  • Synonym symbol(s) AU, MSK19, CD239, LU
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text component of a cluster of three genes, APOC2, SE, LU
    STRUCTURE 12.34 kb     15 Exon(s)    1 Copie(s)
    MAPPING cloned Y linked Y status provisional
    regionally located linked to myotonic dystrophy, APOE and SE
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2448 67 628 - 2004 15278364
  • isoform 1
  • precursor
  • 13 - 2434 - 588 - 2004 15278364
  • isoform 2, including an alternate segment in the 3' coding region
  • precursor
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Endocrinepancreas   highly
    Nervousbrain   lowly
    Reproductivefemale systemovary   
     female systemuterus   
     female systembreastmammary gland  
    Respiratoryrespiratory tractlarynx   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text liver, highly in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five Ig domains and N-glycosylation sites
  • a single transmembrane domain
  • a short C-terminal cytoplasmic tail
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Bcam (73.6pc)
    homolog to murine Bcam (73.4pc)
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    text
  • linked to the rythrocyte cytoskeleton through a direct interaction with spectrin (An 2008)
  • this interaction regulates its adhesive receptor function (An 2008)
  • basic FUNCTION
  • basal cell adhesion molecule may be having a role in erythropoiesis
  • may have a role in signal transduction, cell-cell adhesion and/or cell-substrate adhesion
  • B-CAM/Lu is the critical receptor for sickle red blood cells adhesion to the extracellular matrix protein laminin, an interaction thought to contribute to the pathogenesis of sickle cell-related vaso-occlusive events (Eyler 2006)
  • involved in abnormal sickle red blood cell (RBC) adhesion to components of the vascular wall
  • may have a critical role in facilitating the accumulation of monocytes and macrophages, thereby exacerbating renal injury
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding directly to laminin alpha 5 via alpha 5 LG3 module
  • BCAM is a specific receptor for LAMA5, a major component of basement membranes in various tissues
  • preferential binding of Lu/BCAM to LAMA5 promotes tumor cell migration
  • BCAM is a suppressive oncoprotein, and FBI1/AKIRIN2 is involved in tumorigenicity and metastasis of hepatoma through the downregulation of suppressive oncogenes
  • interaction between ITGA4 and BCAM proteins has been recently shown, suggesting that Lu/BCAM may have a role in leukocyte recruitments in inflamed tissues
  • cell & other
    REGULATION
    Other is under developmental control in liver and is regulated during differenciation
    cleaved by MMP14 (Niiya 2009)
    up-regulated following malignant transformation in some cell types
    phosphorylation by PKA enhances adhesion to laminin
    ASSOCIATED DISORDERS
    corresponding disease(s) LU
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian carcinoma
    constitutional     --over  
    in homozygous sickle red blood cells (RBCs) (SS-RBCs) than normal RBCs and it is critically dependent on the cAMP signaling pathway on both normal and SS-RBCs
    tumoral fusion      
    recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene may contribute to vasoocclusion in sickle cell disease
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    bloodhemoglobin 
    function-blocking antibody against Lu/BCAM should be useful for not only investigating cell adhesion to LAMA5 but also for developing drugs to inhibit sickle cell vaso-occlusion
    ANIMAL & CELL MODELS