Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BAZ2B contributors: mct - updated : 17-03-2012
HGNC name bromodomain adjacent to zinc finger domain, 2B
HGNC id 963
Location 2q24.2      Physical location : 160.175.491 - 160.473.059
Synonym symbol(s) WALp4, FLJ45644, KIAA1476, DKFZp434H071, DKFZp762I0516
DNA
TYPE functioning gene
STRUCTURE 297.57 kb     37 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
37 - 8145 240.3 2168 - 2000 10662543
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
Digestivepancreas exocrine   moderately
 pharynx   highly
Endocrineneuroendocrinepituitary  predominantly
Reproductivefemale systemovary  highly
 male systemtestis  moderately
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal WAC domain
  • a receptor interacting domains (LXXLL)
  • a BAZ1 and a BAZ2 domains
  • a WAKZ motif adjacent to a (C4HC3) PHD-type zinc finger motif
  • a C terminal bromodomain, an exclusive protein domain known to recognize acetyl-lysine residues on proteins and might play an important role in chromatin remodeling and gene transcription regulation
  • a DDT domain
  • an MBD (methyl-CpG-binding) domain
  • HOMOLOGY
    interspecies homolog to rattus Baz2b (88.7 pc)
    homolog to murine Baz2b (88.3 pc)
    Homologene
    FAMILY
  • bromodomain genes family
  • WAL family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may play a role in transcriptional regulation
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • likely component of chromatin remodeling complexes
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with ISWI
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Sudden cardiac death (SCD)
    Variant & Polymorphism other
  • risk allele implicated in prolonged QRS/QT intervals, showing increased risk of SCD
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS