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FLASH GENE
Symbol BATF contributors: mct - updated : 29-05-2018
HGNC name basic leucine zipper transcription factor, ATF-like
HGNC id 958
Location 14q24.3      Physical location : 75.988.783 - 76.013.327
Synonym name
  • SF-HT-activated gene 2
  • activating transcription factor B
  • B-cell activating transcription factor
  • Synonym symbol(s) SFA2, B-ATF, BATF1, SFA-2, B-ATF1
    DNA
    TYPE functioning gene
    STRUCTURE 24.55 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    C14orf115 14q24.2 chromosome 14 open reading frame 115 RPS2P2 14 ribosomal protein S2 pseudogene 2 NPC2 14q24.3 Niemann-Pick disease, type C2 HBLD1 14q24.2 HESB like domain containing 1 C14orf141 14q24.2 chromosome 14 open reading frame 141 LTBP2 14q24.3 latent transforming growth factor beta binding protein 2 KIAA0317 14q22.1-q24.3 latent transforming growth factor beta binding protein 2 C14orf111 14q24.2 chromosome 14 open reading frame 111 C14orf170 14q24.3 chromosome 14 open reading frame 170 FLJ36749 14q24.2 hypothetical protein FLJ36749 LOC390494 14 similar to DC3 DLST 14q24.3 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) RPS6KL1 14q24.2 ribosomal protein S6 kinase-like 1 PGF 14q24.3 placental growth factor, vascular endothelial growth factor-related protein EIF2B2 14q24.3 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa MLH3 14q24.3 mutL homolog 3 (E. coli) LOC387998 14 similar to Acylphosphatase, organ-common type isozyme (Acylphosphate phosphohydrolase) (Acylphosphatase, erythrocyte isozyme) C14orf140 14q24.2 chromosome 14 open reading frame 140 NEK9 14q24.2 NIMA (never in mitosis gene a)- related kinase 9 TMP21 14q24.3 NIMA (never in mitosis gene a)- related kinase 9 LOC338918 14q24.2 hypothetical LOC338918 FOS 14q24.3 v-fos FBJ murine osteosarcoma viral oncogene homolog LOC341912 14q24.2 similar to developmental pluripotency associated 5; embryonal stem cell specific gene 1 JDP2 14q24.3 jun dimerization protein 2 BATF 14q24 basic leucine zipper transcription factor, ATF-like C14orf58 14q24.2 chromosome 14 open reading frame 58 RPS24P2 14 ribosomal protein S24 pseudogene 2 C14orf1 14q24.3 chromosome 14 open reading frame 1 KIAA0998 14q24.3 chromosome 14 open reading frame 1 TGFB3 14q24.3 transforming growth factor, beta 3 MGC16028 14q24.3 MGC16028 similar to RIKEN cDNA 1700019E19 gene C14orf118 14q22.1-q24.3 chromosome 14 open reading frame 118 ESRRB 14q24.3 estrogen-related receptor beta
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 953 14 125 - 2016 26970726
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     tonsils   predominantly
    Respiratorylung   moderately
    Skin/Tegumentskin   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell Homo sapiens
    Lymphoid/Immunelymphocyte
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion blood, lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • basic leucine zipper (bZIP) domain
  • conjugated PhosphoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • Activator protein-1 family /ATF superfamily
  • bZIP family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • acting as a negative regulator of AP-1 mediated transcription by binding to Jun proteins
  • BATF is a central regulator of the Th9 phenotype and contributes to the development of allergic inflammation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text blocking transformation by RAS and FOSx
    PATHWAY
    metabolism
    signaling
    a component
  • forming heterodimers with JUN, JUNB and JUND
  • INTERACTION
    DNA binding as an heterodimer to the 12-O-tetradecanoylphorbol-13-acetate response element (TRE) (consensus: 5'-TGA[CG]TCA-3') and weaker at the cAMP responsive region (CRE) (consensus: 5'- GTGACGT[AC][AG]-3')
    RNA
    small molecule
    protein
  • proteins of the JUN family
  • IFI35
  • role of BATF in CD4(+) T cell subsets and in CD8(+) T cells
  • BATF/JUNB and BATF/JUN complexes play important roles in osteoarthritic cartilage destruction through regulating anabolic and catabolic gene expression in chondrocytes
  • cell & other
    REGULATION
    induced by EB virus in B cells
    inhibited by HTLV1 in T cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    retinoic acid (RA) signaling and BATF productions are activated in IgAN (Immunoglobulin A Nephropathy) patients compared with controls
    constitutional     --over  
    in non-steroid-treated asthmatic children
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    allergyasthm 
    novel target for antiasthma interventions
    ANIMAL & CELL MODELS