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FLASH GENE

Symbol

BARX2

contributors: mct - updated : 09-06-2012

HGNC name	BARX homeobox 2
HGNC id	956

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q24.3      Physical location : 129.245.880 - 129.322.173
Synonym name	BarH-like homeobox 2
Synonym symbol(s)	MGC133369, MGC133368

DNA

TYPE	functioning gene
STRUCTURE	76.29 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

regionally located in the Jacobsen syndrome critical region

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed BARX2 4 - 1767 31.06 279 - 2000 1085479

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly   salivary gland         Reproductive female system breast mammary gland   highly   male system prostate       Respiratory respiratory tract larynx     highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular

cell lineage	ectodermal cells
cell lines
fluid/secretion

at STAGE

physiological period

pregnancy

Text	craniofacial structures during development, mesenchyme of the limb, placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	DNA binding, helix-turn-helix protein
	a highly conserved proline/serine/threonine domain

HOMOLOGY

interspecies

homolog to murine barx1

intraspecies

homolog to BARX1

Homologene

FAMILY

BAR homeobox family

CATEGORY

transcription factor , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus

basic FUNCTION	maybe regulating gene expression, morphogenesis, and differentiation
	maybe a biological factor involved in determining sensitivity or resistance to the cytotoxic effects of cisplatin
	influencing cellular differentiation in various developmental contexts
	regulating gene expression by binding to DNA elements containing paired TAAT motifs that are separated by a poly(T) sequence
	BARX2 and ESR1 may coordinately regulate cell growth, survival and invasion pathways that are critical to breast cancer progression
	cooperates with other muscle-expressed transcription factors to regulate the early cytoskeletal remodeling events that underlie efficient myoblast differentiation
	regulates plasticity of immature myofibers and might act as a molecular switch controlling cell differentiation and proliferation
	regulates expression of matrix metalloproteinases (MMPs) and epithelial cell migration through the extracellular matrix
	required for FGF10-induced lacrymal gland bud elongation
	function specific to ocular gland development
	likely functional network involving BARX2, FGF10 and MMPs that plays an essential role in regulating branching morphogenesis of the ocular glands
	marker for embryonic and adult myoblasts and required for normal postnatal muscle growth and repair
	important regulator of muscle growth and repair that acts via the control of satellite cell proliferation and differentiation

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	BARX2 and ESR1 proteins bind to different ESR1 gene promoters and regulate the expression of alternatively spliced mRNAs that encode 66 and 46 kDa ESR1 protein isoforms
	interacting with FGF10 (BARX2 and FGF10 cooperate in the regulation of MMPs)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in ovarian cancer (suppressor of ovarian cancer progression )

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Barx2(-/-) mice show defective lacrimal gland morphogenesis, absence of the harderian (HG), and meibomian (MG)] glands and eyelid fusion
	mice lacking the Barx2 gene show reduced postnatal muscle growth, muscle atrophy, and defective muscle repair