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FLASH GENE
Symbol BARX2 contributors: mct - updated : 09-06-2012
HGNC name BARX homeobox 2
HGNC id 956
Location 11q24.3      Physical location : 129.245.880 - 129.322.173
Synonym name BarH-like homeobox 2
Synonym symbol(s) MGC133369, MGC133368
DNA
TYPE functioning gene
STRUCTURE 76.29 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
regionally located regionally located in the Jacobsen syndrome critical region
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1767 31.06 279 - 2000 1085479
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
 salivary gland    
Reproductivefemale systembreastmammary gland highly
 male systemprostate   
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandular  
cell lineage ectodermal cells
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text craniofacial structures during development, mesenchyme of the limb, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DNA binding, helix-turn-helix protein
  • a highly conserved proline/serine/threonine domain
  • HOMOLOGY
    interspecies homolog to murine barx1
    intraspecies homolog to BARX1
    Homologene
    FAMILY
  • BAR homeobox family
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • maybe regulating gene expression, morphogenesis, and differentiation
  • maybe a biological factor involved in determining sensitivity or resistance to the cytotoxic effects of cisplatin
  • influencing cellular differentiation in various developmental contexts
  • regulating gene expression by binding to DNA elements containing paired TAAT motifs that are separated by a poly(T) sequence
  • BARX2 and ESR1 may coordinately regulate cell growth, survival and invasion pathways that are critical to breast cancer progression
  • cooperates with other muscle-expressed transcription factors to regulate the early cytoskeletal remodeling events that underlie efficient myoblast differentiation
  • regulates plasticity of immature myofibers and might act as a molecular switch controlling cell differentiation and proliferation
  • regulates expression of matrix metalloproteinases (MMPs) and epithelial cell migration through the extracellular matrix
  • required for FGF10-induced lacrymal gland bud elongation
  • function specific to ocular gland development
  • likely functional network involving BARX2, FGF10 and MMPs that plays an essential role in regulating branching morphogenesis of the ocular glands
  • marker for embryonic and adult myoblasts and required for normal postnatal muscle growth and repair
  • important regulator of muscle growth and repair that acts via the control of satellite cell proliferation and differentiation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BARX2 and ESR1 proteins bind to different ESR1 gene promoters and regulate the expression of alternatively spliced mRNAs that encode 66 and 46 kDa ESR1 protein isoforms
  • interacting with FGF10 (BARX2 and FGF10 cooperate in the regulation of MMPs)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in ovarian cancer (suppressor of ovarian cancer progression )
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Barx2(-/-) mice show defective lacrimal gland morphogenesis, absence of the harderian (HG), and meibomian (MG)] glands and eyelid fusion
  • mice lacking the Barx2 gene show reduced postnatal muscle growth, muscle atrophy, and defective muscle repair