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FLASH GENE
Symbol BARX1 contributors: mct - updated : 25-11-2015
HGNC name BARX homeobox 1
HGNC id 955
Location 9q22.32      Physical location : 96.713.910 - 96.717.608
Synonym name BarH-like homeobox 1
DNA
TYPE functioning gene
STRUCTURE 3.70 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
OGN 9q22.3 osteoglycin (osteoinductive factor, mimecan) OMD 9p22.3 osteomodulin ASPN 9q22-q31 asporin (LRR class 1) ECM2 9q22.3 extracellular matrix protein 2, female organ and adipocyte specific C9orf12 9q21.33-q22.31 chromosome 9 open reading frame 12 BICD2 9q22.1-q22.3 chromosome 9 open reading frame 12 ANKRD19 9q22.32 ankyrin repeat domain 19 BA526D8.4 9q22.32 KRAB box containing C2H2 type zinc finger bA526D8.4 LOC389773 9 LOC389773 LOC340518 9q22.32 similar to Alox15 protein FGD3 9q22 FGD1 family, member 3 MGC26847 LOC389774 9 LOC389774 MGC11115 9q22.32 hypothetical protein MGC11115 LOC389775 9 LOC389775 NINJ1 9q22.3 ninjurin 1 PRKWNK2 9q22.3 protein kinase, lysine deficient 2 C9orf10OS 9q22.32 chromosome 9 open reading frame 10 opposite strand C9orf10 9q22.31 chromosome 9 open reading frame 10 PHF2 9q22.31 PHD finger protein 2 BARX1 9q12 BarH-like homeobox 1 PTP9Q22 9q22.32 protein tyrosine phosphatase PTP9Q22 HCP24 9q22.32 cytochrome c, somatic pseudogene ZNF169 9q22.31 zinc finger protein 169 DKFZp434I1117 9q22.32 hypothetical protein DKFZp434I1117 FLJ14753 9q22.32 hypothetical protein FLJ14753 FBP2 9q22.3 fructose-1,6-bisphosphatase 2 FBP1 9q22.3 fructose-1,6-bisphosphatase 1 FLJ14675 9q22.33 hypothetical protein FLJ14675 FANCC 9q22.3 Fanconi anemia, complementation group C
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1498 27.2 254 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach     Homo sapiensFetal
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal polyalanine tract
  • a nuclear localization signal (NLS) overlapping with the homeodomain (helix-turn-helix motif)
  • a highly conserved poline/serine/threonine domain, 3' of the homeo domain
  • HOMOLOGY
    interspecies ortholog to murine Barx1
    Homologene
    FAMILY
  • BAR homeobox family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional activator/repressor or both
  • as in the developing stomach, but distinct from the spleen, BARX1 control of thoracic foregut specification and tracheo-esophageal septation is tightly associated with down-regulation of adjacent Wnt pathway activity
  • changes in BARX1 function likely in early vertebrates were among the key innovations fostering the evolution of skeletal joints
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • potent BARX1 functions in intestinal rotation and stomach myogenesis occur through ISL1, PITX1, SIX2 and PITX2, intermediary transcription factors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by promoter methylation in colorectal cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS