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FLASH GENE

Symbol

BANP

contributors: mct/npt - updated : 03-12-2024

HGNC name	BTG3 associated nuclear protein
HGNC id	13450

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q24.2      Physical location : 87.985.037 - 88.110.923
Synonym name	scaffold/matrix associated region 1 at the T cell receptor beta locus
	BEN domain containing 1
Synonym symbol(s)	FLJ20538, SMARBP1, SMAR1, DKFZp761H172, FLJ10177, BEND1

DNA

TYPE	functioning gene
STRUCTURE	128.08 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017869 12 splicing 2215 NP_060339 51 469 - 2023 37086783 NM_079837 13 splicing 2281 NP_524576 53.4 491 - 2023 37086783 NM_001384941 13 - 2787 NP_001371870 - 402 - 2023 37086783 NM_001384931 13 - 2783 NP_001371860 - 511 - 2023 37086783 NM_001384936 12 - 2675 NP_001371865 - 475 - 2023 37086783 NM_001384925 13 - 2774 NP_001371854 - 508 - 2023 37086783 NM_001384918 13 - 2765 NP_001371847 - 505 - 2023 37086783 NM_001384916 12 - 2657 NP_001371845 - 469 - 2023 37086783 NM_001384921 12 - 2648 NP_001371850 - 466 - 2023 37086783 NM_001384928 13 - 2735 NP_001371857 - 514 - 2023 37086783 NM_001384919 13 - 2708 NP_001371848 - 505 - 2023 37086783 NM_001384922 12 - 2591 NP_001371851 - 466 - 2023 37086783 NM_001384927 14 - 2425 NP_001371856 - 508 - 2023 37086783 NM_001384923 13 - 2299 NP_001371852 - 466 - 2023 37086783 NM_001384939 13 - 2354 NP_001371868 - 405 - 2023 37086783 NM_001384920 14 - 2557 NP_001371849 - 505 - 2023 37086783 NM_001384943 12 - 2237 NP_001371872 - 366 - 2023 37086783 NM_001384942 13 - 2345 NP_001371871 - 402 - 2023 37086783 NM_001384944 12 - 2228 NP_001371873 - 363 - 2023 37086783 NM_001384929 13 - 2350 NP_001371858 - 514 - 2023 37086783 NM_001384935 13 - 2341 NP_001371864 - 511 - 2023 37086783 NM_001173540 13 - 2299 NP_001167011 - 497 - 2023 37086783 NM_001384937 12 - 2233 NP_001371866 - 475 - 2023 37086783 NM_001384938 12 - 2224 NP_001371867 - 472 - 2023 37086783 NM_001386991 14 - 2398 NP_001373920 - 530 - 2023 37086783 NM_001173539 12 - 2323 NP_001167010 - 505 - 2023 37086783 NM_001384926 12 - 2332 NP_001371855 - 508 - 2023 37086783 NM_001173541 12 - 2206 NP_001167012 - 466 - 2023 37086783 NM_001386992 14 - 2389 NP_001373921 - 527 - 2023 37086783

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Lymphoid/Immune spleen       highly Reproductive female system breast         female system placenta     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid         Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous optic nerve

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	putative DNA binding domain
	multimerization domain
	a BEN (BANP, E5R, and NAC1) domain binding to a CGCG DNA sequence or an AAA-containing matrix attachment regions DNA sequence

HOMOLOGY

interspecies

homolog to murine Satb1

Homologene

FAMILY	cuticular collagen family
	BANP/SMAR1 family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies

basic FUNCTION	modulaing chromatin and acting as negative regulators of the TCRbeta enhancer
	tumor suppressor protein can modulate NF-KB transactivation and inhibit tumorigenesis by regulating NF-KB target genes (Singh 2009)
	is one such nuclear matrix associated protein whose expression is drastically reduced in higher grades of breast cancer
	BANP is an important player in EP300-TP53 regulated DNA damage signalling pathway and can exert its effect on apoptosis in a transcription independent manner
	BANP is a strong CpG island (CGI) activator that controls essential metabolic genes in pluripotent stem and terminally differentiated neuronal cells
	opens chromatin and activates CpG-island-regulated genes
	negatively regulates adipogenesis
	BANP regulates transcription of metabolic genes via a CGCG-containing motif called the BANP motif
	is indispensable for the DNA damage response and chromosome segregation during mitosis
	is required for cell-cycle progression and cell survival by regulating DNA damage responses and chromosome segregation during mitosis
	can induce vascular endothelial cells (VECs) senescence by promoting TP53 phosporylation and nuclear retention
	BANP and BEND3 preferentially bind DNA bearing unmethylated CpG motifs, and they function as CpG island-binding proteins

CELLULAR PROCESS	nucleotide, replication
	nucleotide, repair
	nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	BTG3
	interacting with histone deacetylation complex 1, SIN3, and pocket retinoblastomas to form a multiprotein repressor complex
	may also interact with a specific nuclear matrix/scaffold-associated region (MAR)
	is sensitive to TP53 and acts as a stress inducer as well as a regulator in the TP53 regulatory network
	can also regulate apoptosis in the presence of HDAC1, depending on the stress induced by it
	TOPORS binds on the BANP promoter and its occupancy increases upon LPS treatment
	BANP acts as a repressor of signal transducer and activator of transcription 3 (STAT3) transcription
	CDC20 mediated proteasomal degradation of BANP during adipogenesis
	functions likely as a negative regulator of adipogenesis by inhibiting PPARG expression in differentiating adipocytes

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in high grade breast cancer consequently enhancing the tumor-promoting functions of NF-KB (Singh 2009)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS