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FLASH GENE
Symbol BANP contributors: mct/npt - updated : 08-04-2009
HGNC name BTG3 associated nuclear protein
HGNC id 13450
Location 16q24.2      Physical location : 87.985.037 - 88.110.923
Synonym name
  • scaffold/matrix associated region 1 at the T cell receptor beta locus
  • BEN domain containing 1
  • Synonym symbol(s) FLJ20538, SMARBP1, SMAR1, DKFZp761H172, FLJ10177, BEND1
    DNA
    TYPE functioning gene
    STRUCTURE 125.89 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 splicing 2230 51 469 - Birot, Singh (2009)
    13 splicing 2296 53.4 491 - Birot, Singh (2009)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunespleen   highly
    Reproductivefemale systembreast   
     female systemplacenta  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoptic nerve
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative DNA binding domain
  • multimerization domain
  • HOMOLOGY
    interspecies homolog to murine Satb1
    Homologene
    FAMILY
  • cuticular collagen family
  • BANP/SMAR1 family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • modulaing chromatin and acting as negative regulators of the TCRbeta enhancer
  • tumor suppressor protein can modulate NF-KB transactivation and inhibit tumorigenesis by regulating NF-KB target genes (Singh 2009)
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, repair
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BTG3
  • interacting with histone deacetylation complex 1, SIN3, and pocket retinoblastomas to form a multiprotein repressor complex
  • may also interact with a specific nuclear matrix/scaffold-associated region (MAR)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in high grade breast cancer consequently enhancing the tumor-promoting functions of NF-KB (Singh 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS