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FLASH GENE
Symbol BAIAP2L1 contributors: mct/npt/pgu - updated : 19-04-2013
HGNC name BAI1-associated protein 2-like 1
HGNC id 21649
Location 7q21.3      Physical location : 97.920.963 - 98.030.427
Synonym name
  • insulin receptor tyrosine kinase substrate
  • brain-specific angiogenesis inhibitor 1-associated protein
  • 2-like protein 1
    Synonym symbol(s) IRTKS, FLJ42275
    DNA
    TYPE functioning gene
    STRUCTURE 109.47 kb     14 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3682 - 511 - 2007 17430976
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     stomach   highly
    Respiratoryrespiratory tractlarynx   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved N-terminal F-actin bundling domain (IMD domain)
  • SH3 domain regulating the cytoskeleton , and the specificity pocket of this SH3 has evolved to accommodate a polyproline type II helical peptide analogously to docking of the canonical PxxP by the conserved BAIAP2L1 SH3 proline-binding pocket
  • short C-terminal (Ct) extension present on BAIAP2L1 which resembles a WASP-homology 2 (WH2) motif
  • HOMOLOGY
    interspecies homolog to murine Baiap2l1
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • induces clusters of short actin bundles rather than filopodia-like protrusions
  • having an unique role as transducer of signalling, linking the protruding membrane to the underlying actin cytoskeleton
  • scaffold protein involved in plasma membrane deformation and actin cytoskeleton remodeling
  • SRC-stimulated BAIAP2L1 phosphorylation is essential for its function in cell motility
  • IRSTP53-like protein inhibited TP53-induced apoptosis and depressed its transcription activity
  • novel regulator of TP53, modulating low level of MDM2-mediated TP53 ubiquitination in unstressed cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • substrate for insulin receptor and binds RAC
  • bound directly to TP53 and increased TP53 ubiquitination and cytoplasmic localization
  • interacted with MDM2 and promoted low levels of MDM2-mediated TP53 ubiquitination
  • cell & other
    REGULATION
    Phosphorylated by active SRC, and disruption of SRC-stimulated BAIAP2L1 phosphorylation abolished the effect of BAIAP2L1 on wound closure
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with FGFR3, in bladder carcinoma 3)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS