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FLASH GENE
Symbol BAG4 contributors: mct - updated : 21-06-2012
HGNC name BCL2-associated athanogene 4
HGNC id 940
Location 8p11.23      Physical location : 38.034.105 - 38.068.537
Synonym name
  • silencer of death domains
  • BAG-family molecular chaperone regulator-4
  • Synonym symbol(s) SODD, BAG-4, DKFZp586O2022
    DNA
    TYPE functioning gene
    STRUCTURE 36.71 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC392212 8 similar to ribosomal protein L23 MRPS7P1 8p11.22 mitochondrial ribosomal protein S7 pseudogene 1 FKSG2 8p11.2 apoptosis inhibitor LOC392213 8 similar to SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1; BAF57 LOC389647 8 LOC389647 LOC389648 8 LOC389648 FLJ14299 8p11.23 hypothetical protein FLJ14299 C8orf2 8p11.2 chromosome 8 open reading frame 2 PROSC 8p11.2 proline synthetase co-transcribed homolog (bacterial) GPR124 8p11.23 G protein-coupled receptor 124 BRF2 8q11.23 BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like RCP 8p11.22 Rab coupling protein MGC33309 8p11.23 hypothetical protein MGC33309 ASH2L 8p11.2 ash2 (absent, small, or homeotic)-like (Drosophila) STAR 8p11.2 steroidogenic acute regulatory protein LSM1 8p11.2 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) BAG4 8p11.23 BCL2-associated athanogene 4 KIAA0725 8p11.22 BCL2-associated athanogene 4 HTPAP 8p11.23 HTPAP protein WHSC1L1 8p12-p11.2 Wolf-Hirschhorn syndrome candidate 1-like 1 FLJ25409 8p11.22 hypothetical protein FLJ25409 FGFR1 8p12 fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) LOC389649 8 hypothetical gene supported by AK125570 LOC286140 8p11.22 similar to ring finger protein 5 TACC1 8p11 transforming, acidic coiled-coil containing protein 1 PLEKHA2 8p11.21 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 FLJ90724 8p11.22 hypothetical protein FLJ90724 BLP1 8p11.22 BBP-like protein 1 ADAM9 8p12 a disintegrin and metalloproteinase domain 9 (meltrin gamma) ADAM32 8p11.22 a disintegrin and metalloprotease domain 32 ADAM5 8p11.22 a disintegrin and metalloproteinase domain 5 ADAM3A 8p21-p12 a disintegrin and metalloproteinase domain 3a (cyritestin 1) ADAM18 8p11.21 a disintegrin and metalloproteinase domain 18 ADAM2 8p11.2 a disintegrin and metalloproteinase domain 2 (fertilin beta) INDO 8p11.2 indoleamine-pyrrole 2,3 dioxygenase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4478 - 457 - 2002 12058034
    4 - 4370 - 421 - 2002 12058034
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    C terminal BAG domain binding Hsc70/Hsp70 and Bcl2 (containing three-helix bundles; each helix in this bundle is three to four turns shorter than its counterpart in BAG1, which reduces the length of the domain by one-third.)
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • negative regulator of Hsp70 chaperone activity
  • having apoptosis regulator activity, and involved in apoptosis
  • chaperone-regulating protein, functioning as a negative regulator for APOBEC1-mediated apoB mRNA editing through its ability to suppress the Hsp/Hsc70 chaperone activity
  • breast cancer oncogene that can work in combination to influence the transformed phenotype in human mammary epithelial cells
  • involvement in the propagation of ovarian cancer
  • novel regulator of PI3K/Akt signaling to the actin cytoskeleton
  • inhibits PI(3,4,5)P3 degradation following growth factor stimulation, and in its absence, the enhanced 5-ptase activity reduces Akt activation, leading to reduced Akt-dependent signaling to the actin cytoskeleton
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • BAG4 forms a complex with several 5-ptase family members, including INPPL1, INPP5D, INPP5K
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the ATPase domain of HSP70/HSC chaperones
  • binding to the death domain of TNFRSF1A
  • in the absence of TNF and thereby preventing binding of adapter molecules such as TRADD or TRAF2
  • binds to the death domain of TNFRSF12
  • binds to APOBEC1 via its N-terminal region independent of the BAG domain
  • complexes with and inhibits the catalytic activity of the inositol polyphosphate 5-phosphatase INPP5K
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic cancer compared with normal pancreas, correlating with high Akt activation, even in the absence of cell stimulation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may represent a potential prognostic marker for cute lymphoblastic leukemia
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    provide a basis for the development of molecular therapeutics modulating these survival pathways
    ANIMAL & CELL MODELS