Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BAG2 contributors: mct - updated : 18-09-2007
HGNC name BCL2-associated athanogene 2
HGNC id 938
Location 6p12.3-p11.2      Physical location : 57.037.103 - 57.050.010
Synonym name BAG-family molecular chaperone regulator-2
Synonym symbol(s) BAG-2, KIAA0576, MGC149462
DNA
TYPE functioning gene
STRUCTURE 12.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - D6S294 - BAG2 - D6S257 - D6S1695 - D6S1658 - D6S430 - qter
Authors Gene Map (98)
Physical map
LOC391930 6 similar to ribosomal protein L31 LOC391931 6 similar to replication protein A3, 14kDa; replication protein A3 (14kD) GCLC 6p12 glutamate-cysteine ligase, catalytic subunit LOC391932 6 similar to bA345L23.2 (novel protein with BTB/POZ (broad complex Tramtrack bric-a-brac/Pox virus and zinc finger) domain) LRRC1 6p12.1 leucine-rich repeat-containing 1 C6orf142 6p12.2-p12.1 chromosome 6 open reading frame 142 TINAG 6p12-p11.2 tubulointerstitial nephritis antigen CLNS1B 6p12 chloride channel, nucleotide-sensitive, 1B LOC391933 6 similar to Transforming protein p21b (K-Ras 2B) (Ki-Ras) (c-K-ras) LOC221344 6p12.1 hypothetical LOC221344 LOC389399 6 LOC389399 C6orf143 6p12.1 chromosome 6 open reading frame 143 HCRTR2 6p11-q11 hypocretin (orexin) receptor 2 LOC389400 6 similar to IVFI9356 HMGCLL1 6p12.1 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 LOC391934 6 similar to nitrogen fixation cluster-like BMP5 6p11.1 bone morphogenetic protein 5 COL21A1 6p12.3-p11.2 collagen, type XXI, alpha 1 LOC221341 6p12.1 similar to RCC1-like BPAG1 6p12-p11 bullous pemphigoid antigen 1, 230/240kDa C6orf65 6p12.1 chromosome 6 open reading frame 65 MRPL30P1 6p12.1 chromosome 6 open reading frame 65 KIAA1586 6p12.1 KIAA1586 ZNF451 6p12.1 zinc finger protein 451 BAG2 6p12.3-p11.2 BCL2-associated athanogene 2 RAB23 6p11.2-p12.3 RAB23, member RAS oncogene family PRIM2A 6p12-p11.1 primase, polypeptide 2A, 58kDa LOC391935 6 similar to glyceraldehyde 3-phosphate dehydrogenase LOC346245 6p12.1 similar to Chromatin assembly factor 1 subunit C (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-Ip48) (Retinoblastoma binding protein p48) (Retinoblastoma-binding protein 4) (RBBP-4) (MSI1 pr LOC389401 6 similar to SMA3 protein LOC391936 6 similar to glyceraldehyde 3-phosphate dehydrogenase LOC389402 6 similar to Chromatin assembly factor 1 subunit C (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-Ip48) (Retinoblastoma binding protein p48) (Retinoblastoma-binding protein 4) (RBBP-4) (MSI1 pr
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three BAG domains of BAG1, BAG2, and BAG3 interact specifically with the HSPA8 ATPase domain
  • C terminal BAG domain binding HSPA8/HSP70 ATPase domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • negative regulator of Hsp70 chaperone activity
  • inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release
  • compete with RPL29 for binding to the HSPA8/HSP70 ATPase domain and promote substrate release
  • inhibits the ubiquitin ligase activity of STUB1 by abrogating the STUB1/E2 cooperation and stimulates the chaperone-assisted maturation of CFTR
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the ATPase domain of HSP70/HSC chaperones
  • associates with STUB1 as part of a ternary complex with HSPA8, and BAG2 (provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by STUB1)
  • BAG2 contributes to HSP70 stabilization in tissues other than testes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS