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Symbol BAG1 contributors: mct/pgu - updated : 08-01-2015
HGNC name BCL2-associated athanogene
HGNC id 937
Location 9p21.1      Physical location : 33.252.471 - 33.264.759
Synonym name
  • hormone receptor binding protein RAP46
  • glucorticoid receptor associated-protein
  • BAG family molecular chaperone regulator
  • Bcl-2 associating athanogene-1 protein
  • Synonym symbol(s) RAP46, BAG-1, HAP
    TYPE functioning gene
    STRUCTURE 12.29 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    Binding site
    text structure no TATA, several transcription factor binding sites
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392302 9 similar to argininosuccinate synthetase APTX 9p13.3 aprataxin DNAJA1 9p13-p12 DnaJ (Hsp40) homolog, subfamily A, member 1 SMU-1 9p12 homolog of C. elegans smu-1 B4GALT1 9p13 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 SPINK4 9p12 serine protease inhibitor, Kazal type 4 BAG1 9p12 BCL2-associated athanogene HSPC177 NFX1 9p12 nuclear transcription factor, X-box binding 1 AQP7 9p13 aquaporin 7 AQP3 9p13 aquaporin 3 NOL6 9p13.2 nucleolar protein family 6 (RNA-associated) bA255A11.3 9p12 FLJ35740 pseudogene LOC389711 9 similar to hypothetical protein DKFZp434F1719
    TRANSCRIPTS type messenger
    text different subcellular localizations for the distinct forms, differing by chain and N terminal domain
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1332 46 274 - 2009 19595997
  • also called BAG-1M or RAP46
  • interacting with steroid receptors
  • inhibits the transactivation of the glucocorticoid receptor via recruitment of corepressors
  • increase of BAG-1M in human AD patients, which is both physically and functionally associated to the two major molecular markers of AD
  • HSPBP1 and BAG-1M differentially regulate steroid hormone receptor function
  • 7 initiation site 3885 38.7 345 - 2007 17662274
  • also called BAG-1L, p50 or variant 1/isoform BAG-1L
  • inhibiting HSC70 function
  • containing a nuclear localization signal, which is not present in the other isoforms
  • predominantly localized in the cell nucleus and suppressing heat shock-induced apoptosis
  • increased oestrogen-dependent transcription in breast cancer cells, enhancing oestrogen-dependent transcription
  • 7 initiation site 3885 - 230 - 2007 17662274
    also called BAG-1S, p33, p36 or variant 1/isoform BAG-1S
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousnervespinal nervesciatic   Homo sapiens
    Reproductivefemale systemuteruscervix highly
    SystemCellPubmedSpeciesStageRna symbol
    NervousSchawnn cell Homo sapiens
    cell lineage
    cell lines breast and lung cell lines
    at STAGE
  • a N terminal ubiquitin-like domain
  • a nuclear localization signal (NLS)
  • a C terminal BAG domain binding Hsc70/Hsp70 ATPase domain
  • conjugated GlycoP
    interspecies homolog to murine Bag1
    ortholog to yeast Bag101 and Bag102
  • ubiquitin family
  • CATEGORY chaperone/stress , signaling , receptor
    SUBCELLULAR LOCALIZATION     intracellular
  • nuclear localization in laryngeal carcinoma increased the risk of recurrence after irradiation
  • mainly localizes to the nucleus during neuronal development, but shifts to the cytosol upon neuronal differentiation
  • basic FUNCTION
  • negative regulator of Hsp70 chaperone activity
  • steroid hormone regulation
  • multifunctional protein playing key role in the development and progression of cancer and determining response to therapy
  • playing a role in the suppression of the PPP1R15A -mediated cellular stress response and in the survival of cells undergoing stress
  • displaying potent neuroprotective activity against stroke
  • can influence cellular response to stress by multiple mechanisms, potentially influenced by the cell type and nature of the stress signal
  • functioning to inhibit the proteasomal degradation of Tau protein, leading to an accumulation of Tau protein
  • (this role having implications for possible therapeutics of tauopathies that up-regulate the chaperone apparatus of the cell and also for the pathogenesis of the disease)
  • plays a key role in affective resilience and in regulating recovery from both manic-like and depression-like behavioral impairments
  • suppress apoptosis and enhance neuronal differentiation
  • acts in a dual role by inhibition of lesion-induced apoptosis and interaction with the inhibitory ROCK signalling cascade
  • inhibits the transactivating functions of TP73 and provide new insight into the mechanisms that control the expression of TP73
  • involved in different cell processes linked to cell survival
  • able to affect leukemia cell fate by influencing the expression of anti-apoptotic proteins crucial for AML maintenance
  • is a repressor of TGFB1, suggesting a new role for BAG1 in colorectal tumorigenesis
  • suppress apoptosis and enhance neuronal differentiation
  • its expression increased during the cyclic adenosine monophosphate (cAMP)-induced Schwann cell differentiation process
  • co-chaperone BAG1 that plays an important role in targeting structurally perturbed proteins for degradation via the ubiquitin-proteasome pathway
  • CELLULAR PROCESS cell life, antiapoptosis
    a component
    small molecule
  • several types of proteins, including BCL2 family proteins
  • some tyrosine-kinase receptors such as hepatocyte growth factor receptor MET, PDGFR
  • steroid receptors (RAP46)
  • interaction with chaperone molecules
  • interact with the HSC70 and HSP70 heat shock proteins (cardioprotective role)and with FKBP5
  • interacting with glucocorticoids receptor (regulates GR function primarily by attenuating its nuclear translocation and transactivation functions)
  • interaction with PARK7 (BAG1 restores formation of functional PARK7 L166P dimers and PARK7 chaperone activity)
  • bound BCR-ABL with a high affinity (directly routes immature BCR-ABL for proteasomal degradation)
  • BAG1 may regulate TGFB1 expression, a key cytokine in normal colonic tissue homoeostasis
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cervical, breast (invasive) carcinomas, lung cancer cell lines and in laryngeal carcinoma
    tumoral     --over  
    at relatively early stages in colorectal tumorigenesis
  • to Alzheimer disease
  • to bipolar disorder (BPD)
  • Variant & Polymorphism
    Candidate gene
    Therapy target
    candidate for new therapeutic strategies including gene therapy and small-molecule drugs for reducing brain injury during cerebral ischemia
    candidate for new therapeutic strategies including gene therapy and small-molecule drugs for reducing brain injury during neurodegenerative diseases
    psychiatrybipolar disorder 
    . therapies designed to enhance BAG1 function may lead to treatments for both the manic and depressive phases of BPD, as well as modulating the effects of stress
    promising molecule to be further examined as a putative therapeutic tool in neurorestorative strategies.
    may thus be useful target for improved and more individualized treatments for patients with esophageal squamous cell carcinoma