Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | BAD | contributors: mct/pgu - updated : 03-12-2009 |
HGNC name | BCL2-associated agonist of cell death |
HGNC id | 936 |
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Location | 11q13.1 Physical location : 64.037.300 - 64.052.176 |
Synonym name | |
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Synonym symbol(s) | BBC2, BCL2L8, BBC6 |
DNA |
TYPE | functioning gene |
STRUCTURE | 14.88 kb 4 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter |
Binding site | |
text structure |
MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| ovarian cancer, prostate cancer | fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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secondary structure | an helix |
mono polymer | heteromer , dimer |
HOMOLOGY |
interspecies | homolog to rattus Bad (77.8pc) |
homolog to murine Bad (77.8pc) |
Homologene |
FAMILY |
CATEGORY | regulatory |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,organelle,mitochondria,outer | |
intracellular,cytoplasm,cytosolic | |
text | translocated to cytosol when inactivated by phosphorylation |
basic FUNCTION | |
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CELLULAR PROCESS | cell cycle |
cell life, cell death/apoptosis | |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component | |
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INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
activated by | Ca2+ calmodulin |
TSC2 |
inhibited by | phosphorylation by Raf-1 |
phospharylation at Ser 118 by CAPK (protein kinase A) | |
phosphorylation by RSK-MAP kinase pathway | |
phosphorylated by PIM2 on serine 112, which accounts in part for its ability to reverse Bad-induced cell death |
repressed by | PI3 kinases pathway |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |