motifs/domains
| BTB (broad complex-tramtrack-bric-à-brac) domain, POZ (pox virus and zinc finger) protein interaction domain, at the N-terminus which is responsible both for homodimerization and interaction with other factors such as the MAZ-related factor (MZAR), and recruits transcriptional co-repressors and class II histone deacetylases |
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a CNC (cap'n'collar) and a basic leucine zipper (bzip) domain |
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a b-Zip domain, protein -protein interaction domain at the C-terminus which mediates heterodimerization with small Maf bZIPs |
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a basic leucine zipper domain that mediates DNA binding |
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an unstructured region important for heme binding, and consequently for its functional regulation |
basic FUNCTION
| regulation of B cell development |
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key regulator of nucleic acid-triggered antiviral responses in cells |
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acts as a transcriptional repressor by forming a Bach2/MafK heterodimer, which binds to the Maf recognition element (MARE) and the antioxidant-responsive element (ARE) |
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involved in neuronal differentiation, immunoglobulin class switching, and somatic hypermutation |
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encoding a transcription factor required for class switch DNA recombination (CSR) |
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regulates B-cell differentiation and function through BLIMP1-dependent and -independent gene regulatory network |
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suppresses effector memory-related genes to maintain the naive T-cell state and regulates generation of effector-memory T cells |
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is required for affinity maturation of B cells |
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is a crucial mediator of negative selection at the pre-B cell receptor checkpoint and a safeguard against leukemogenesis |
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is required for the functional maturation of AMs (alveolar macrophage) and pulmonary homeostasis, independently of the GM-CSF signaling |
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BCL6 and BACH2 cooperate to orchestrate gene expression patterning in germinal center (GC) B cells through both transcriptional and biochemical mechanisms, which collectively determine the proper initiation and timing of terminal differentiation |
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required for class switch recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin genes in activated B cells |
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is essential for the function of alveolar macrophages, and therefore, orchestrates both acquired and innate immunity at multiple points |
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BACH2 functions with BACH1 and EBF1 to promote B cell development by repressing myeloid genes in common lymphoid progenitor (CLP) ( |
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transcriptional repressor BACH2 regulates humoral and cellular immunity, including antibody class switching |
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BACH1 and BACH2 work in a complementary manner to maintain the normal function of the alveolar macrophages (AMs) and surfactant homeostasis in the lung |