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FLASH GENE
Symbol BACH2 contributors: mct - updated : 10-04-2015
HGNC name BTB and CNC homology 1, basic leucine zipper transcription factor 2
HGNC id 14078
Location 6q15      Physical location : 90.636.247 - 91.006.627
Synonym symbol(s) EVI59, BTBD25
DNA
TYPE functioning gene
STRUCTURE 370.38 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site
text structure DNA binding sites
MAPPING cloned Y linked N status provisional
Physical map
SPACA1 6q16.1 sperm acrosome associated 1 CNR1 6q14-q15 cannabinoid receptor 1 (brain) LOC391951 6 similar to ribosomal protein S14 ACTBP8 6q13 actin, beta pseudogene 8 RNGTT 6q16 RNA guanylyltransferase and 5'-phosphatase HCP16 6q15 cytochrome c, somatic pseudogene PNRC1 6q16.1 proline-rich nuclear receptor coactivator 1 SRrp35 6q16.1 serine-arginine repressor protein (35 kDa) ACY1L2 6q16.1 aminoacylase 1-like 2 GABRR1 6q13-q15.3 gamma-aminobutyric acid (GABA) receptor, rho 1 GABRR2 6q14-q16.3 gamma-aminobutyric acid (GABA) receptor, rho 2 UBE2J1 6q16.1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) RRAGD 6q15-q16 Ras-related GTP binding D ANKRD6 6q14.2-q16.1 ankyrin repeat domain 6 DJ122O8.2 6q14.2-q16.1 hypothetical protein dJ122O8.2 MDN1 6q15 MDN1, midasin homolog (yeast) CASP8AP2 6q16.1 CASP8 associated protein 2 CX62 6q15-q16 connexin 62 LOC285793 6q16.1 hypothetical LOC285793 BACH2 6q15 BTB and CNC homology 1, basic leucine zipper transcription factor 2 MAP3K7 6q16.1-q16.3 mitogen-activated protein kinase kinase kinase 7
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 9289 - 841 - 2000 10949928
7 - 9118 - 841 - 2000 10949928
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx    
Lymphoid/Immunelymph node    
 thymus    
 tonsils    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell Homo sapiens
Lymphoid/Immunelymphocyte
Lymphoid/ImmuneT cell Homo sapiens
cell lineage B lymphocytic cell lines, lymphoid
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • BTB (broad complex-tramtrack-bric--brac) domain, POZ (pox virus and zinc finger) protein interaction domain, at the N-terminus which is responsible both for homodimerization and interaction with other factors such as the MAZ-related factor (MZAR), and recruits transcriptional co-repressors and class II histone deacetylases
  • a CNC (cap'n'collar) and a basic leucine zipper (bzip) domain
  • a b-Zip domain, protein -protein interaction domain at the C-terminus which mediates heterodimerization with small Maf bZIPs
  • a basic leucine zipper domain that mediates DNA binding
  • an unstructured region important for heme binding, and consequently for its functional regulation
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Bach2
    Homologene
    FAMILY
  • CNC-type basic leucine zipper (bZIP) transcription factor family
  • BTB-basic region leucine zipper factor family
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • regulation of B cell development
  • key regulator of nucleic acid-triggered antiviral responses in cells
  • acts as a transcriptional repressor by forming a Bach2/MafK heterodimer, which binds to the Maf recognition element (MARE) and the antioxidant-responsive element (ARE)
  • involved in neuronal differentiation, immunoglobulin class switching, and somatic hypermutation
  • encoding a transcription factor required for class switch DNA recombination (CSR)
  • regulates B-cell differentiation and function through BLIMP1-dependent and -independent gene regulatory network
  • suppresses effector memory-related genes to maintain the naive T-cell state and regulates generation of effector-memory T cells
  • is required for affinity maturation of B cells
  • is a crucial mediator of negative selection at the pre-B cell receptor checkpoint and a safeguard against leukemogenesis
  • is required for the functional maturation of AMs (alveolar macrophage) and pulmonary homeostasis, independently of the GM-CSF signaling
  • BCL6 and BACH2 cooperate to orchestrate gene expression patterning in germinal center (GC) B cells through both transcriptional and biochemical mechanisms, which collectively determine the proper initiation and timing of terminal differentiation
  • required for class switch recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin genes in activated B cells
  • is essential for the function of alveolar macrophages, and therefore, orchestrates both acquired and innate immunity at multiple points
  • BACH2 functions with BACH1 and EBF1 to promote B cell development by repressing myeloid genes in common lymphoid progenitor (CLP) (
  • transcriptional repressor BACH2 regulates humoral and cellular immunity, including antibody class switching
  • BACH1 and BACH2 work in a complementary manner to maintain the normal function of the alveolar macrophages (AMs) and surfactant homeostasis in the lung
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • BCR-ABL/BACH2
  • MAF -related oncoprotein/BACH2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding with MAFK NF-E2 binding sites, coordinating transcription activation and repression by MAFK
  • interacting with NCOR2 and HDAC4 (Hoshino 2007)
  • MEN1 binding at the BACH2 locus and the BACH2 expression are decreased in the senescent CD4 T cells
  • represses the expression of PRDM1 repressor and thereby inhibits terminal differentiation of B cells to plasma cells
  • heme binds to an intrinsically disordered region of BACH2 and alters its conformation
  • cell & other
    REGULATION
    induced by BCR/ABL oncogene (transcriptional)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in primary chronic myeloid leukemia cells
    tumoral fusion      
    BACH2-BCL2L1 fusion gene resulting from a t(6;20)(q15;q11.2) chromosomal translocation in Burkitt lymphoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS