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FLASH GENE
Symbol B4GALT2 contributors: mct/npt - updated : 01-12-2015
HGNC name UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
HGNC id 925
Location 1p34-p33      Physical location : 44.444.865 - 44.456.839
Synonym name
  • UDP galactose:beta-N-acetylglucosamine beta 1,4,galactosyltransferase 2
  • lactose synthase A protein
  • N-acetyllactosamine synthase
  • Synonym symbol(s) B4GT2, beta4Gal-T2
    EC.number 2.4.1.38, 2.4.1.22, 2.4.1.90
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    EBNA1BP2 1p35-p33 EBNA1 binding protein 2 FLJ32000 1p34.1 hypothetical protein FLJ32000 LOC256339 1p34.1 similar to ENSANGP00000010412 MGC17299 1p34.1 hypothetical protein MGC17299 MGC52423 1p34.1 hypothetical protein MGC52423 TIE 1p34 tyrosine kinase with immunoglobulin and epidermal growth factor homology domains CDC20 9q13-q21 CDC20 cell division cycle 20 homolog (S. cerevisiae) MPL 1p34 myeloproliferative leukemia virus oncogene ELOVL1 1p34.1 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 MED8 1p34.1 mediator of RNA polymerase II transcription, subunit 8 homolog (yeast) LOC388625 1 similar to FLJ00408 protein HT036 1p34.1 hypothetical protein HT036 PTPRF 1p34 protein tyrosine phosphatase, receptor type, F JMJD2 1p34.1 jumonji domain containing 2 SIAT6 1p34.1 sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase) ARTN 1p32-p31.3 artemin IPO13 1p34.1 importin 13 DPH2L2 1p34 diptheria toxin resistance protein required for diphthamide biosynthesis-like 2 (S. cerevisiae) ATP6V0B 1p32.3 ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c'' B4GALT2 1p34-p33 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 MGC45441 1p34.1 hypothetical protein MGC45441 SLC6A9 1p33 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 LOC391034 1 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 FLJ40160 1p34.1 hypothetical protein FLJ40160 LOC128208 1p34.1 similar to dJ675G8.1 (novel zinc finger protein) DMAP1 1p34 DNA methyltransferase 1 associated protein 1 PRNPIP 1p32 prion protein interacting protein FLJ10597 1p34.1 hypothetical protein FLJ10597 FLJ22353 1p34.1 hypothetical protein FLJ22353 LOC339541 1p34.1 hypothetical LOC339541 LOC256686 1p34.1 hypothetical LOC256686 KIF2C 1p32.2 kinesin family member 2C RPS8 1p32.2-p32.1 ribosomal protein S8 LOC391035 1 similar to 40S ribosomal protein S15a VMD2L2 1p33-p32.3 Homo sapiens vitelliform macular dystrophy 2-like protein 2 (VMD2L2), mRNA. CNK 1p34.1 cytokine-inducible kinase LOC343521 1p34.1 similar to hypothetical protein 4833401D15 LOC388626 1 LOC388626
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1950 - 136 - Almeida, Gregory (2006)
    non functional
    - - 1890 41 372 - Almeida, Gregory (2006)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Reproductivefemale systemuteruscervix highly
     female systemovary   
     male systemtestis   
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal hydrophobic signal sequence
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • beta-4- galactosyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • trans Golgi
  • type II transmembrane glycoprotein
  • basic FUNCTION
  • synthesis of N acetylactosamine in glycolipids and glycoproteins
  • one of the enzymes transferring galactose to the terminal N-acetylglucosamine of complex-type N-glycans and its expression is significantly altered during oncogenesis
  • play important roles in the extension of N- and O-linked glycans involved in several biological events
  • major regulator of the synthesis of glycans involved in neuronal development
  • specific enzyme complex of B4GALT2 with B3GAT1 plays an important role in the biosynthesis of B3GAT1 carbohydrate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alpha lactalbumin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS