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FLASH GENE
Symbol B3GNT3 contributors: - updated : 27-01-2005
HGNC name UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
HGNC id 13528
Location 19p13.1      Physical location : 17.905.918 - 17.924.385
Synonym name
  • transmembrane protein 3
  • putative type II membrane protein
  • Synonym symbol(s) TMEM3, B3GN-T3, HP10328, B3GAL-T8, B6A6
    EC.number 2.4.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 17.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    digestiveesophagus    
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestinejejunum  
     stomach    
    Respiratoryrespiratory tracttrachea   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines colon cancer cell line
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal cytoplasmic domain
  • a transmembrane segment
  • a stem region
  • a catalytic domain with three N glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine B3gnt3
    Homologene
    FAMILY beta-1,3-N-acetylglucosaminyltransferase family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • type II transmembrane protein
  • basic FUNCTION
  • biosynthesis of poly-N-acetyllactosamine chainsof the backbone structure of dimeric sialyl Lewis x
  • involved in L selectin biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text lymphocyte homing,lymphocyte trafficking
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS