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FLASH GENE
Symbol B3GAT1 contributors: mct - updated : 01-12-2015
HGNC name beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
HGNC id 921
Location 11q25      Physical location : 134.248.399 - 134.281.812
Genatlas name human natural killer-1
Synonym name
  • leukocyte antigen 7
  • cell differentiation antigen CD57, identified by monoclonal antibodies Leu7, L183, L187
  • UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase
  • glucuronosyltransferase P
  • Synonym symbol(s) GLCATP, CD57, GlcAT-P, GlcUAT-P, HNK-1, HNK1, LEU7, NK-1, NK1
    EC.number 2.4.1.135
    DNA
    TYPE like-sequence
    STRUCTURE 33.48 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    OPCML 11q25 opioid binding protein/cell adhesion molecule-like FLJ25851 11q25 spergen-1 LOC283172 11q25 similar to h2-calponin KIAA1030 11q25 similar to h2-calponin JAM3 11q25 junctional adhesion molecule 3 KIAA0056 11q25 KIAA0056 protein MGC10485 11q25 hypothetical protein MGC10485 THY28 11q25 thymocyte protein thy28 ACAD8 11q25 acyl-Coenzyme A dehydrogenase family, member 8 LOC112937 11q25 hypothetical protein BC011001 FLJ90231 11q25 hypothetical protein FLJ90231 LOC89944 11q25 hypothetical protein BC008326 B3GAT1 11q25 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) LOC341098 11q25 similar to ENSANGP00000020885 LOC390278 11 similar to retinitis pigmentosa GTPase regulator
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 3534 37 334 - 2002 11788581
    unique 5' and u'utr
    6 splicing 3666 37 334 - 2002 11788581
    unique 5' and u'utr
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   lowly
    Nervousbrain   predominantly Homo sapiens
     brainhindbraincerebellum   Mus musculus
     brainlimbic systemhippocampus   Mus musculus
     spinal cord     Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral  predominantly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short cytoplasmic N terminal tail,
  • a hydrophobic transmembrane segment (TM1)
  • a proline rich region
  • a large C terminal catalytic domain with four highly conserved motifs and three potential N glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Glcatp
    Homologene
    FAMILY glucuronyltransferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • key enzyme in the synthesis of HNK-1 carbohydrate epitope on both glycoproteins and glycolipids
  • carbohydrate required for the structural and functional development of the mammalian nervous system, such as the maturation of dendritic spines and the acquisition of synaptic plasticity, respectively
  • mutual catalytic domains of B3GAT1 or B3GAT2 and CHST10 are important and sufficient for formation of an enzyme complex
  • is involved in synaptic plasticity and memory formation
  • highly expressed in the nervous system and is involved in synaptic plasticity and dendritic spine maturation
  • specific enzyme complex of B4GALT2 with B3GAT1 plays an important role in the biosynthesis of B3GAT1 carbohydrate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physical and functional association of glucuronyltransferases and sulfotransferase involved in B3GAT1 biosynthesis
  • on GRIA2 regulates cell surface stability of GRIA2 by modulating the interaction with CDH2
  • CHST10 is a sulfotransferase that forms B3GAT1 glycan on neural cell adhesion proteins and glycolipids, and B3GAT1 is thought to modulate cell adhesion and possibly metastasis
  • novel role for CHST10 as a regulator of the functional glycans on DAG1 other than B3GAT1 biosynthesis
  • CHST10 adds sulfate to glucuronic acid to form a carbohydrate antigen, B3GAT1, in glycoproteins and glycolipids
  • KL expression was associated with expression of the non-sulfated B3GAT1 epitope
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS