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FLASH GENE
Symbol B3GALNT1 contributors: - updated : 25-04-2007
HGNC name beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
HGNC id 918
Location 3q25      Physical location : 160.801.672 - 160.823.160
Synonym name
  • globoside synthase
  • UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3
  • P antigen synthase
  • Synonym symbol(s) B3GT3,GLCT3, B3GALT3, P, P1, GLOB, Gb4Cer
    EC.number 2.4.1.79
    DNA
    TYPE functioning gene
    STRUCTURE 215.00 kb     6 Exon(s)
    text structure one coding exon
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    text All variants encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3319 35 331 - Amado
    - - 3438 35 331 - Amado
    - - 3224 35 331 - Amado
    - - 3292 35 331 - Amado
    - - 3642 35 331 - Amado
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    digestiveesophagus    
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestinejejunum  
     stomach    
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratoryrespiratory tracttrachea   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal cytoplasmic domain of 19 or 17AA
  • a transmembrane segment of 14AA
  • a stem region plus a catalytic domain of 298AA
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine B3galt3
    intraspecies homolog to beta 3 GALT1
    Homologene
    FAMILY beta 1-3 galactosyltransferase gene family
    CATEGORY enzyme , signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II membrane protein
    basic FUNCTION
  • N-linked glycoprotein glycosylation strictly specific for UDP-galactose
  • synthesis of type I carbohydrate chains
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS