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FLASH GENE
Symbol AZGP1 contributors: mct/pgu - updated : 26-08-2010
HGNC name alpha-2-glycoprotein 1, zinc-binding
HGNC id 910
Location 7q22.1      Physical location : 99.564.351 - 99.573.735
Synonym name
  • Zn-alpha-2-glycoprotein
  • Zn-alpha-2-GP
    • Synonym symbol(s) ZAG, ZA2G, ZNGP1
    DNA
    TYPE functioning gene
    STRUCTURE 10.27 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1247 34.3 298 - 1993 830756
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connectiveadipose   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     adipocyte
    cell lineage
    cell lines
    fluid/secretion plasma, seminal plasma, urine, saliva, sweat
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Azgp1
    homolog to C.elegans F52C6.9
    Homologene
    FAMILY
  • MHC class I family
    • CATEGORY secretory , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • stimulating lipid degradation in adipocytes
  • causing the extensive fat losses associated with some advanced cancers
  • plays an important role in the mobilization and utilization of stored lipids, and may play an important role in the regulation of adipose mass in obesity and cachexia
  • lipid-mobilizing factor involved in regulating lipid metabolism and adiposity
  • tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-beta-mediated ERK signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid degradation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • binding to polyunsaturated fatty acids
    • REGULATION
    Other
  • its expression is regulated by glucocorticoids
    • ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in pancreatic ductal adenocarcinoma
    tumoral     --low  
    in prostate carcinoma with risk of metastatic progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS