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FLASH GENE
Symbol AZGP1 contributors: mct/pgu - updated : 26-08-2010
HGNC name alpha-2-glycoprotein 1, zinc-binding
HGNC id 910
Location 7q22.1      Physical location : 99.564.351 - 99.573.735
Synonym name
  • Zn-alpha-2-glycoprotein
  • Zn-alpha-2-GP
  • Synonym symbol(s) ZAG, ZA2G, ZNGP1
    DNA
    TYPE functioning gene
    STRUCTURE 10.27 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    ZNF394 7q22.1 zinc finger protein 394 ZFP95 7q22 zinc finger protein 95 homolog (mouse) DKFZp727G131 7q22.1 hypothetical protein DKFZp727G131 VIK 7q22.1 vav-1 interacting Kruppel-like protein ZNF498 7q22.1 zinc finger protein 498 CYP3A5 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 5 CYP3A5P1 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 1 CYP3A7 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 7 CYP3A5P2 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 2 CYP3A4 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 4 CYP3A43 7q21.1 cytochrome P450, family 3, subfamily A, polypeptide 43 TRIM4 7q22-q31.1 tripartite motif-containing 4 AZGP1 7q22.1 alpha-2-glycoprotein 1, zinc LOC392078 7 hypothetical gene supported by BC022382 ZNF36 7q21.3-q22.1 zinc finger protein 36 (KOX 18) ZNF38 7q21-q22 zinc finger protein 38 ZNF3 7q22.1 zinc finger protein 3 (A8-51) COPS6 7q22.1 zinc finger protein 3 (A8-51) MCM7 7q21.3-q22.1 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) AP4M1 7q22.1 adaptor-related protein complex 4, mu 1 subunit TAF6 7q11 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa MGC40499 7q22.1 hypothetical protein MGC40499 LOC255374 7q22.1 similar to hypothetical protein MGC49416 LOC392079 7 similar to ribosomal protein L7 LOC389541 7 similar to CG14977-PA FLJ10925 7q22.1 hypothetical protein FLJ10925 GAL3ST-4 7q22 hypothetical protein FLJ10925 GPC2 7q22.1 glypican 2 (cerebroglycan) STAG3 7q22 stromal antigen 3 GATS 7q22.1 opposite strand transcription unit to STAG3 LOC392080 7 similar to opposite strand transcription unit to Stag3; Gats protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1247 34.3 298 - 1993 830756
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connectiveadipose   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     adipocyte
    cell lineage
    cell lines
    fluid/secretion plasma, seminal plasma, urine, saliva, sweat
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Azgp1
    homolog to C.elegans F52C6.9
    Homologene
    FAMILY
  • MHC class I family
  • CATEGORY secretory , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • stimulating lipid degradation in adipocytes
  • causing the extensive fat losses associated with some advanced cancers
  • plays an important role in the mobilization and utilization of stored lipids, and may play an important role in the regulation of adipose mass in obesity and cachexia
  • lipid-mobilizing factor involved in regulating lipid metabolism and adiposity
  • tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-beta-mediated ERK signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid degradation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • binding to polyunsaturated fatty acids
  • REGULATION
    Other
  • its expression is regulated by glucocorticoids
  • ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in pancreatic ductal adenocarcinoma
    tumoral     --low  
    in prostate carcinoma with risk of metastatic progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS