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FLASH GENE
Symbol AURKC contributors: mct - updated : 05-12-2019
HGNC name aurora kinase C
HGNC id 11391
Corresponding disease
LHPS male infertility with large-headed polyploid spermatozoa
Location 19q13.43      Physical location : 57.742.376 - 57.746.915
Synonym name
  • serine/threonine kinase 13 (aurora/IPL1-like)
  • aurora/Ipl1/Eg2 protein 2
  • aurora/Ipl1-related kinase 3
    • Synonym symbol(s) AIE2, AIK3, STK13, AurC, aurora-C
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 4.54 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1261 - 309 - 1998 9809744
    7 splicing 1120 - 290 - 2005 15670791
  • aurora C-SV
  • using an alternate splice site at the 5' end of the first intron and an alternate upstream translation initiation site compared to variant 1
    • 7 splicing 1125 - 275 - 1998 9799611
  • using an alternate splice site at the 5' end of the first intron and an alternate downstream translation initiation site compared to variant 1
    		•
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    cell cycle     cell cycle, checkpoint, G2M
    Text at the late pachytene stage
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • catalytic domain
  • central serine/threonine kinase domain
    • mono polymer complex
    HOMOLOGY
    interspecies homolog to Drosophila Aurora
    homolog to yeast S.cerevisiae IPI1
    ortholog to murine Aurkc
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • Aurora subfamily
    • CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • localized to centrosome from anaphase to cytokinesis
  • co-localized with Aurora B and Survivin (BIRC5) in mitotic cells
  • preferentially expressed during oocyte meiosis
    • basic FUNCTION
  • may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis
  • playing a key role in the organization of the kinetochore
  • being essential for normal chromosome segregation
  • having an involvement in oncogenic signal transduction
  • required for cytokinesis
  • cycle-regulatory serine-threonine kinases implicated in the function of the centrosomes, kinetechores, chromosome dynamics, and cytokinesis
  • having specialized functions in mammalian spermatogenesis
  • support the mitotic progression in the absence of Aurora-B suggesting that the two kinases may have overlapping functions
  • possible role of Aurora-C in telophase and/or cytokinesis
  • implicated in the regulation of mitosis
  • has a role in the later stage of mitosis, when an interaction with TACC1 may be relevant for the correct progression of the cell cycle
  • crucial function of aurora C during the early embryonic cycles
    • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • chromosomal passenger protein that forms complexes with Aurora-B and inner centromere protein (INCENP), which are known passenger proteins
  • member of the chromosomal passenger complex
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • can also be associated with Aurora B and BIRC5
  • TACC1 is a substrate of AURKC
  • role for HASPIN as a regulator of bipolar spindle assembly by regulating AURKC function at acentriolar microtubule-organizing centers (MTOCs) in oocytes
  • AURKB/AURKC) are activated by binding to the C-terminal domain of INCENP
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LHPS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancers and several cancer cell lines
    Susceptibility to primary infertility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS