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FLASH GENE
Symbol AUP1 contributors: mct/npt - updated : 14-01-2013
HGNC name ancient ubiquitous protein 1
HGNC id 891
Location 2p13      Physical location : 74.753.775 - 74.756.974
DNA
TYPE functioning gene
STRUCTURE 3.20 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MTHFD2 2p12 methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase SLC4A5 2p13 solute carrier family 4, sodium bicarbonate cotransporter, member 5 DCTN1 2p13 dynactin 1 (p150, glued homolog, Drosophila) LOC388963 2 similar to Retinol dehydrogenase 12 LOC257200 2p13.1 similar to high mobility group AT-hook 1 FLJ12953 2p13.1 hypothetical protein FLJ12953 similar to Mus musculus D3Mm3e RTKN 2p13 rhotekin HMGA1L4 2p13.1 high mobility group AT-hook 1-like 4 WBP1 2p12 WW domain binding protein 1 GCS1 2p13 WW domain binding protein 1 MRPL53 2p13.1 mitochondrial ribosomal protein L53 LOC151534 2p13.1 hypothetical protein BC009264 FLJ14397 2p13.1 hypothetical protein FLJ14397 FLJ12788 2p13.1 hypothetical protein FLJ12788 NSPC1 2p13.1 likely ortholog of mouse nervous system polycomb 1 TLX2 2p13.1-p12 T-cell leukemia, homeobox 2 DQX1 2p12 T-cell leukemia, homeobox 2 AUP1 2p13 ancient ubiquitous protein 1 PRSS25 2p13.3 protease, serine, 25 LOXL3 2p13.3 lysyl oxidase-like 3 DOK1 2p13 docking protein 1, 62kDa (downstream of tyrosine kinase 1) LOC130951 2p13.1 hypothetical protein BC014602 SEMA4F 2p13 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 1466 46 410 ubiquitous Peng (unpublished)
- splicing 1664 53 476 ubiquitous Peng (unpublished)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a hydrophobic region close to the N terminus that inserts into the membrane such that both termini are found in the cytoplasm
  • two conserved cytoplasmic domains
  • an acyltransferase domain
  • a CUE domain, UBA-like domains that bind ubiquitin, that may serve a regulatory function to control polyubiquitin chain formation on AUP1 or the dislocated ER protein
  • a C-terminal UBE2G2 binding domain (G2BR)
  • HOMOLOGY
    interspecies ortholog to murine Aup1
    homolog to C.elegans hypothetical protein F44B9.5
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text
  • found in both the ER and in lipid droplets
  • basic FUNCTION
  • playing a role in cellular metabolism
  • playing a crucial role in the alpha(IIb)beta(3) inside-out signalling
  • potential involvement in the integrin signaling (
  • contributes to the degradation of misfolded ER proteins and affects the intracellular abundance of lipid droplets
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    integrin signaling
    a component
  • associates with the mammalian SYVN1-SEL1L complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with UBE2J1 and FAF2 (are required for the exit of a type I ER membrane protein from the ER)
  • binds UBE2G2 and this interaction is dependent on the C terminus of AUP1 that constitutes a G2BR domain
  • recruits both E2 and E3 enzymes, UBE2G2 and SYVN1, respectively
  • lipid droplet-associated, that is one of several proteins that copurify with AMFR, and involved in ubiquitination of HMGCR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    results in increased lipid droplets
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS