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FLASH GENE
Symbol AUH contributors: - updated : 12-02-2007
HGNC name AU RNA binding protein/enoyl-Coenzyme A hydratase
HGNC id 890
Corresponding disease
MTGA1 3-methylglutaconicaciduria type I
Location 9q22      Physical location : 93.976.098 - 94.124.206
Synonym name
  • AU-binding protein/enoyl-CoA hydratase
  • methylglutaconyl-CoA hydratase, mitochondrial
  • EC.number 4.2.1.18
    DNA
    TYPE functioning gene
    STRUCTURE 148.00 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see ROR2
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Nervousbraindiencephalonhypothalamus  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    separate domains for RNA binding and hydratase activity
    mono polymer homomer , hexamer
    isoforms Precursor 40-kDa precursor protein
    HOMOLOGY
    interspecies ortholog to murine Auh
    Homologene
    FAMILY enoyl-CoA hydratase/isomerase family
    CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • bifunctional enzyme with both RNA-binding and enoyl-CoA-hydratase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS detoxification
    text elimination of short life RNAs
    PATHWAY
    metabolism aminoacid
    signaling
    leucine degradation
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MTGA1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS