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FLASH GENE
Symbol ATXN2L contributors: mct - updated : 11-07-2015
HGNC name ataxin 2-like
HGNC id 31326
Location 16p11      Physical location : 28.834.413 - 28.848.556
Synonym name
  • ataxin 2 related protein
  • PAB1-binding protein 1
  • Synonym symbol(s) A2D, A2LG, A2LP, A2RP
    DNA
    TYPE functioning gene
    STRUCTURE 14.00 kb     0 Exon(s)
    motif repetitive sequence   triplet
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 4425 - 1075 - 2002 11784712
  • variant A
  • 23 - 3851 - 1062 - 2002 11784712
  • variant B
  • lacking a segment of the 3'coding region and the 3' utr
  • 24 - 4039 - 1097 - 2002 11784712
  • variant C
  • lacking a segment of the 3' coding region and 3' utr
  • 23 - 3820 - 1044 - 2002 11784712
  • varaint D
  • lacking a segment of 3' coding region and 3' utr
  • 23 - 3797 - 1044 - 2002 11784712
  • variant E
  • lacking a segment of the 3' coding region and 3' utr
  • 23 - 3874 - 1052 - 2002 11784712
  • variant F
  • lacking a segment of the 3' coding region and 3' UTR
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     spleen    
     thymus    
    Reproductivemale systemtestis   
    cell lineage
    cell lines megakaryoblast cell line
    fluid/secretion
    at STAGE
    physiological period fetal
    Text fetal kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies paralog to ATXN2
    Homologene
    FAMILY member of the SCA (spinocerebelar ataxia) family
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • cytokine signaling
  • may be acting to repress the ability of PAB1 to negatively regulate polyadenylation
  • is asymmetrically dimethylated , and the nuclear localization of ATXN2L is altered under methylation inhibition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated wth MPL
  • ATXN2L associates with known interaction partners of ATXN2, the RNA helicase DDX6 and the poly(A)-binding protein, and with ATXN2 itself
  • associates with the protein arginine-N-methyltransferase 1 (PRMT1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS