Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ATRIP contributors: mct - updated : 30-05-2015
HGNC name ATR interacting protein
HGNC id 33499
Location 3p21.31      Physical location : 48.488.217 - 48.507.054
Synonym name ATM and Rad3-related-interacting protein
Synonym symbol(s) FLJ12343, MGC20625, MGC21482, MGC26740, DKFZp762J2115, AGS1
EC.number 3.1.11.2
DNA
TYPE functioning gene
STRUCTURE 18.84 kb     13 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2428 82.8 764 - 2007 17638878
13 - 2509 85.7 791 - 2007 17638878
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a TOPBP1-interacting region necessary for the association of TOPBP1 and ATR, for TOPBP1-mediated activation of ATR, and for cells to survive and recover DNA synthesis following replication stress
  • a conserved checkpoint protein recruitment domain (CRD)
  • HOMOLOGY
    Homologene
    FAMILY
  • ATRIP family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • with ATR (ATR-interacting protein) coordinate checkpoint responses to DNA damage and replication stress
  • conserved role in monitoring meiotic chromosome metabolism
  • ATRIP SUMOylation promotes ATR activation by providing a unique type of protein glue that boosts multiple protein interactions along the ATR pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ATR-ATRIP kinase complex regulates cellular responses to DNA damage and replication stress
  • ATR and its partner ATRIP exist as a complex and function together in the DNA damage response
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATRIP is a CDK2 substrate and CDK2-dependent phosphorylation of S224 regulates the ability of ATR-ATRIP to promote cell cycle arrest in response to DNA damage
  • ATR functions in a complex with its regulatory partner ATRIP
  • ATR-ATRIP protein kinase complex plays a crucial role in the cellular response to replication stress and DNA damage
  • regulatory partner of ATR, that is modified by SUMO2/3 at K234 and K289
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    mutations in ATRIP the partner protein of ATR required for ATR stability and recruitment to the site of DNA damage, in a Seckel Syndrome patient
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS