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Symbol ATP8B3 contributors: mct - updated : 29-06-2021
HGNC name ATPase, Class I, type 8B, member 3
HGNC id 13535
Location 19p13.3      Physical location : 1.782.075 - 1.812.270
Synonym name
  • aminophospholipid translocase ATP8B3
  • potential phospholipid-transporting ATPase IK
  • potential phospholipid-transporting
    Synonym symbol(s) ATPIK, Saplt
    EC.number 3.6.3.1/ 7.6.2.1
    DNA
    TYPE functioning gene
    STRUCTURE 30.21 kb     32 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 5095 - 1300 - 2003 12880872
    29 - 5043 - 1263 - 2003 12880872
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • cation transport ATPases family (E1-E2 ATPases), subfamily IV
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • ATP8B3 did not bind CDC50A and CDC50B and was invariably present in the ER
  • exclusively expressed in the testis and its expression is likely developmentally regulated during testicular development
  • basic FUNCTION
  • aminophospholipid translocase ATP8B3
  • potential phospholipid-transporting
  • may play a role in acrosome development and/or in sperm function during fertilization
  • potential role for ATP8B3 in sperm cell capacitation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATP8B3 has an ATPase activity and is phosphorylated by an ATP-producing acylphosphate intermediate, which is a signature property of the P-Type ATPases
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS