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FLASH GENE
Symbol ATP6V1F contributors: npt - updated : 24-09-2002
HGNC name ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
HGNC id 16832
Location 7q32      Physical location : 128.502.897 - 128.505.902
Synonym name
  • V-ATPase subunit F
  • V-ATPase 14 kDa subunit
  • human fetus brain mRNA for vacuolar ATPase, complete cds
  • adenosinetriphosphatase 14k chain
    • Synonym symbol(s) VATF, ATP6S14, VMA7, MGC11732, MGC126037, MGC126038
    EC.number 3.6.3.14
    DNA
    TYPE functioning gene
    STRUCTURE 3.00 kb     2 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 691 13 119 - Smith (2003)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrineadrenal gland   highly
     parathyroid   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an ATP catalytic site
    • HOMOLOGY
    interspecies homolog to rattus Rn.6167
    Homologene
    FAMILY
  • V-ATPase F subunit family
    • CATEGORY enzyme , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text clathrin-coated vesicules
    basic FUNCTION
  • generates an electrochemical proton gradient that is acid and positive inside synaptic vesicles
  • play a major role as energizers of animal plasma membranes, especially apical plasma membranes of epithelial cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text hydrogen ion transport
    PATHWAY
    metabolism
    signaling
    ATP synthesis
    a component
  • component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS