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FLASH GENE
Symbol ATP6V1D contributors: np/ - updated : 20-09-2004
HGNC name ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
HGNC id 13527
Location 14q23.3      Physical location : 67.804.589 - 67.826.591
Synonym name
  • V-ATPase D subunit
  • vacuolar H-ATPase subunit D
  • ATPase, H+ transporting, lysosomal, 28 kD accessory protein
  • H(+)-transporting two-sector ATPase, subunit M
  • V-type proton ATPase subunit D
  • Synonym symbol(s) VATD, VMA8, ATP6M
    EC.number 3.6.3.14, 3.6.1.34
    DNA
    TYPE functioning gene
    STRUCTURE 22.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1823 - 247 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
    mono polymer heteromer , octamer
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Vma8p
    ortholog to murine Atp6m
    homolog to C.elegans f55h2.2
    intraspecies
    Homologene
    FAMILY
  • V-ATPase d subunit family
  • CATEGORY enzyme , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    text vacuole; attached to an integral membrane Vo proton pore complex
    basic FUNCTION
  • ATP synthesis
  • acidifying a variety of intracellular compartments using its proton-pumping action
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text hydrogen ion transport
    PATHWAY
    metabolism energetic , drug , other
    signaling
    ATP synthesis
    a component
  • vacuolar H+ ATPase (V-ATPase) subunit
  • subunit of the peripheral V1 complex of vacuolar ATPase
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Vo proton pore complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS